INT150137

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Context Info
Confidence 0.53
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.46
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Kcnn3) cytoplasm (Kcnn3)
Anatomy Link Frequency
neurons 1
mossy fibers 1
Kcnn3 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 16 99.96 Very High Very High Very High
midbrain 12 99.82 Very High Very High Very High
Kinase C 4 91.92 High High
long-term potentiation 20 87.64 High High
Neuronal excitability 13 80.80 Quite High
Dopamine 11 79.12 Quite High
Intracerebroventricular 2 75.20 Quite High
GABAergic 7 54.80 Quite High
Dismenorea 1 54.64 Quite High
Neurotransmitter 6 51.36 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 9 85.84 High High
Targeted Disruption 7 83.60 Quite High
Pre-term Labor 1 75.00 Quite High
Dysmenorrhea 1 54.64 Quite High
Eating Disorder 146 50.00 Quite Low
Phobia 8 50.00 Quite Low
Cognitive Disorder 14 31.92 Quite Low
Appetite Loss 26 5.00 Very Low Very Low Very Low
Congenital Anomalies 26 5.00 Very Low Very Low Very Low
Channelopathies 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we show in WT mice that SK3 transcript and protein are significantly reduced during pregnancy.
Transcription (transcript) of SK3
1) Confidence 0.53 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 18305226 Disease Relevance 0.29 Pain Relevance 0.05
Dopaminergic midbrain neurons express high levels of SK3 mRNA [32, 34, 119] and protein [120].
Transcription (express) of SK3 in neurons associated with midbrain
2) Confidence 0.51 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.31
In the hippocampus, SK3 was found predominantly in the terminal field of the mossy fibers and in fine varicose fibers, thereby suggesting their presynaptic localization.
Transcription (found) of SK3 in mossy fibers associated with hippocampus
3) Confidence 0.47 Published 2005 Journal Ann Gen Psychiatry Section Body Doc Link PMC1260012 Disease Relevance 0.08 Pain Relevance 0.23
Blank et al. [28] found recently that SK3 channel transcript and protein were more abundant in hippocampi from aged mice (22–24 months) compared to hippocampi from young mice (4–6 months).
Transcription (transcript) of SK3
4) Confidence 0.36 Published 2005 Journal Ann Gen Psychiatry Section Body Doc Link PMC1260012 Disease Relevance 0.09 Pain Relevance 0.28

General Comments

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