INT150138

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Context Info
Confidence 0.54
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.96
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Kcnn3) cytoplasm (Kcnn3)
Anatomy Link Frequency
brain 4
Kcnn3 (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 6 50.00 Quite Low
Dismenorea 1 44.80 Quite Low
Migraine 8 42.48 Quite Low
headache 2 37.76 Quite Low
Pyramidal cell 40 5.00 Very Low Very Low Very Low
Action potential 40 5.00 Very Low Very Low Very Low
Ventral tegmentum 20 5.00 Very Low Very Low Very Low
nMDA receptor 18 5.00 Very Low Very Low Very Low
long-term potentiation 16 5.00 Very Low Very Low Very Low
Substantia nigra 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Manic Depressive Disorder 8 99.68 Very High Very High Very High
Schizophrenia 28 99.28 Very High Very High Very High
Anorexia 6 92.96 High High
Targeted Disruption 8 83.60 Quite High
Pre-term Labor 1 75.00 Quite High
Dysmenorrhea 1 44.80 Quite Low
Headache 10 42.48 Quite Low
Ataxia 16 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low
Epilepsy 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, we investigated the effects of SK3 channel expression on gestation and parturition, comparing SK3(T/T) mice to wild type (WT) mice.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of SK3
1) Confidence 0.54 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 18305226 Disease Relevance 0.23 Pain Relevance 0
The same factors that prompted the investigations on the possible genetic links between KCNN3 and schizophrenia or bipolar disorder (physiological role of SK3 in neurons, expression pattern of SK3 in brain, polymorphic CAG-repeats in the SK3 amino-terminal region and chromosomal localization of the SK3 gene; see above) led also to studies on its possible involvement in anorexia.
Regulation (role) of Gene_expression (expression) of SK3 in brain associated with manic depressive disorder, anorexia and schizophrenia
2) Confidence 0.23 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.87 Pain Relevance 0
The same factors that prompted the investigations on the possible genetic links between KCNN3 and schizophrenia or bipolar disorder (physiological role of SK3 in neurons, expression pattern of SK3 in brain, polymorphic CAG-repeats in the SK3 amino-terminal region and chromosomal localization of the SK3 gene; see above) led also to studies on its possible involvement in anorexia.
Regulation (pattern) of Gene_expression (expression) of SK3 in brain associated with manic depressive disorder, anorexia and schizophrenia
3) Confidence 0.23 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.86 Pain Relevance 0

General Comments

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