INT150141

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Context Info
Confidence 0.66
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 3.54
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Kcnn3) cytoplasm (Kcnn3)
Anatomy Link Frequency
blood vessel 4
neurons 2
uterine 2
Golgi cells 2
hippocampus 2
Kcnn3 (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 36 99.82 Very High Very High Very High
Pyramidal cell 144 99.04 Very High Very High Very High
Dismenorea 8 98.56 Very High Very High Very High
Hippocampus 40 95.68 Very High Very High Very High
long-term potentiation 68 95.56 Very High Very High Very High
Action potential 144 92.80 High High
Kinase C 28 91.92 High High
amygdala 39 88.48 High High
Limbic system 20 86.88 High High
headache 11 79.80 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 32 100.00 Very High Very High Very High
Schizophrenia 104 99.68 Very High Very High Very High
Dysmenorrhea 8 98.56 Very High Very High Very High
Pre-term Labor 3 97.96 Very High Very High Very High
Anxiety Disorder 15 88.76 High High
Movement Disorders 2 82.12 Quite High
Diplopia 2 80.96 Quite High
Syncope 6 80.36 Quite High
Headache 37 79.80 Quite High
Peripheral Neuropathy 2 79.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dopaminergic midbrain neurons express high levels of SK3 mRNA [32, 34, 119] and protein [120].
Positive_regulation (levels) of Gene_expression (express) of SK3 in neurons associated with midbrain
1) Confidence 0.66 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.31
Although the relative contribution of each of these mechanisms and their possible interplay are still somewhat controversial and might depend on the type of blood vessel and stimulation, a considerable consensus has been reached that the initial step of EDHF-dependent relaxation is the activation of SK (in particular SK3) and IK channels in the endothelium (reviewed in [177–179]), as supported also by findings in genetically modified mice overexpressing or lacking SK3 [181] or lacking IK channels [182].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of SK3 in blood vessel
2) Confidence 0.66 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.12 Pain Relevance 0
Golgi cells express high levels of the SK3 subunit [32].
Positive_regulation (levels) of Gene_expression (express) of SK3 subunit in Golgi cells
3) Confidence 0.58 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.08
In a previous study, the overexpression of small conductance calcium-activated K(+) channel isoform 3 in transgenic mice, Kcnn3(tm1Jpad)/Kcnn3(tm1Jpad) (also known as SK3(T/T)), led to compromised parturition, which indicates that KCNN3 (also known as SK3) plays an important role in the delivery process.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Kcnn3 associated with targeted disruption
4) Confidence 0.50 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 18305226 Disease Relevance 0.17 Pain Relevance 0
In a previous study, the overexpression of small conductance calcium-activated K(+) channel isoform 3 in transgenic mice, Kcnn3(tm1Jpad)/Kcnn3(tm1Jpad) (also known as SK3(T/T)), led to compromised parturition, which indicates that KCNN3 (also known as SK3) plays an important role in the delivery process.
Positive_regulation (calcium-activated) of Gene_expression (overexpression) of Kcnn3 associated with targeted disruption
5) Confidence 0.50 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 18305226 Disease Relevance 0.17 Pain Relevance 0
SK3-overexpressing mice, by contrast, exhibited lower intrauterine pressure over the same period.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of SK3 associated with dismenorea
6) Confidence 0.49 Published 2010 Journal Physiol. Genomics Section Abstract Doc Link 20460604 Disease Relevance 0.40 Pain Relevance 0.42
The authors further suggested that increased hippocampal expression of SK3 channels in aged mice may represent a mechanism that contributes to age-dependent decline in learning and memory and synaptic plasticity.
Positive_regulation (increased) of Gene_expression (expression) of SK3
7) Confidence 0.47 Published 2005 Journal Ann Gen Psychiatry Section Body Doc Link PMC1260012 Disease Relevance 0.09 Pain Relevance 0.24
Thus, a relative deficit of SK channels or even their genetically engineered absence [104] may not yield overt phenotypic outcome, as SK3 overexpression would [28].
Positive_regulation (overexpression) of Gene_expression (overexpression) of SK3
8) Confidence 0.47 Published 2005 Journal Ann Gen Psychiatry Section Body Doc Link PMC1260012 Disease Relevance 1.20 Pain Relevance 0.26
However, the expression of SK3 has been reported to increase with age in the hippocampal formation and correlate with age-dependent deficits in synaptic plasticity and hippocampus-dependent learning [86].
Positive_regulation (increase) of Gene_expression (expression) of SK3 in hippocampus associated with hippocampus
9) Confidence 0.45 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.27
Finally, a rare frameshift mutation has been identified in one schizophrenic patient [231], leading to the expression of a truncated SK3 channel comprising the amino-terminal region but missing the transmembrane domains.
Positive_regulation (leading) of Gene_expression (expression) of SK3 associated with schizophrenia
10) Confidence 0.45 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.72 Pain Relevance 0
Although the relative contribution of each of these mechanisms and their possible interplay are still somewhat controversial and might depend on the type of blood vessel and stimulation, a considerable consensus has been reached that the initial step of EDHF-dependent relaxation is the activation of SK (in particular SK3) and IK channels in the endothelium (reviewed in [177–179]), as supported also by findings in genetically modified mice overexpressing or lacking SK3 [181] or lacking IK channels [182].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of SK3 in blood vessel
11) Confidence 0.42 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.17 Pain Relevance 0
Overexpression of SK3 channels dampens uterine contractility to prevent preterm labor in mice.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of SK3 in uterine associated with pre-term labor
12) Confidence 0.41 Published 2008 Journal Biol. Reprod. Section Title Doc Link 18305226 Disease Relevance 0.25 Pain Relevance 0
The SK channels responsible for these effects are most likely formed by SK1 and SK2 subunits, while no [32, 82] or only weak [36] SK3 expression was detected in the DCN.
Positive_regulation (detected) of Gene_expression (expression) of SK3
13) Confidence 0.39 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.17 Pain Relevance 0.07
The initial rate of [Ca2+]i elevation and its peak were independent of KCa3.1 expression in deoxygenated mouse SAD cells.
Neg (independent) Positive_regulation (independent) of Gene_expression (expression) of KCa3
14) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806905 Disease Relevance 0.08 Pain Relevance 0

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