INT150142

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.82
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Kcnn3) cytoplasm (Kcnn3)
Anatomy Link Frequency
P19 2
cerebellum 1
Kcnn3 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 11 98.82 Very High Very High Very High
Dopamine 16 95.66 Very High Very High Very High
ischemia 1 82.96 Quite High
Dismenorea 3 78.88 Quite High
Action potential 42 74.92 Quite High
antagonist 2 64.96 Quite High
addiction 2 55.00 Quite High
potassium channel 9 50.00 Quite Low
midbrain 12 44.36 Quite Low
Thalamus 2 42.88 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 13 100.00 Very High Very High Very High
Schizophrenia 31 97.56 Very High Very High Very High
Disease 21 97.20 Very High Very High Very High
Obesity 1 94.32 High High
Coronary Heart Disease 1 88.64 High High
Hypertension 1 86.72 High High
Stroke 1 85.60 High High
Cv Unclassified Under Development 1 82.96 Quite High
Dysmenorrhea 3 78.88 Quite High
Ataxia 17 77.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we show in WT mice that SK3 transcript and protein are significantly reduced during pregnancy.
Negative_regulation (reduced) of SK3
1) Confidence 0.59 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 18305226 Disease Relevance 0.30 Pain Relevance 0.06
We also found the force produced by uterine strips from Pregnancy Day 19 (P19) SK3(T/T) mice was significantly less than that measured in WT or SK3 knockout control (SK3(DOX)) uterine strips, and this effect was reversed by application of the SK3 channel inhibitor apamin.
Negative_regulation (application) of SK3 in P19 associated with targeted disruption
2) Confidence 0.43 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 18305226 Disease Relevance 0.32 Pain Relevance 0.08
In transgenic mouse lines, SK3-1B was only detected in DCN neurons within the cerebellum and consequently suppressed all SK-mediated currents in these neurons.
Negative_regulation (suppressed) of SK3-1B in cerebellum associated with targeted disruption
3) Confidence 0.41 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.27 Pain Relevance 0.04
We also found the force produced by uterine strips from Pregnancy Day 19 (P19) SK3(T/T) mice was significantly less than that measured in WT or SK3 knockout control (SK3(DOX)) uterine strips, and this effect was reversed by application of the SK3 channel inhibitor apamin.
Negative_regulation (measured) of SK3 in P19 associated with targeted disruption
4) Confidence 0.37 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 18305226 Disease Relevance 0.32 Pain Relevance 0.07
Changes in the degree and/or pattern of dopamine signaling have been implicated in the pathophysiology of Parkinson’s disease and schizophrenia [121, 203–205]; therefore, it is conceivable that the modulation of SK channel activity, preferably by subtype selective SK3 inhibitors or enhancers, might represent a novel therapeutic strategy for the treatment of these diseases.
Negative_regulation (inhibitors) of SK3 associated with dopamine, disease and schizophrenia
5) Confidence 0.36 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.61 Pain Relevance 0.21
Clearly, the pulmonary vasoconstrictor response to fenfluramine was only partly mediated by 5-HT receptors, inasmuch as the vasoconstrictor potency of the drug was elevated when the K+-channel activity was reduced or altered in transgenic (SK3-T/T) mice [88].
Negative_regulation (reduced) of SK3 associated with targeted disruption and potency
6) Confidence 0.25 Published 2005 Journal Ann Gen Psychiatry Section Body Doc Link PMC1260012 Disease Relevance 1.00 Pain Relevance 0.12

General Comments

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