INT150145

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.11
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Kcnn3) cytoplasm (Kcnn3)
Anatomy Link Frequency
uterus 1
brain 1
dopaminergic neurons 1
Kcnn3 (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 2 98.04 Very High Very High Very High
Dopamine 14 96.16 Very High Very High Very High
Dismenorea 1 95.92 Very High Very High Very High
Substantia nigra 14 94.56 High High
GABAergic 6 89.92 High High
Ventral tegmentum 20 89.52 High High
gABA 2 81.64 Quite High
Glutamate 6 81.28 Quite High
Endocannabinoid 4 77.40 Quite High
potassium channel 6 50.00 Quite Low
Disease Link Frequency Relevance Heat
Manic Depressive Disorder 8 98.98 Very High Very High Very High
Schizophrenia 28 98.58 Very High Very High Very High
Dysmenorrhea 1 95.92 Very High Very High Very High
Anorexia 6 92.96 High High
Targeted Disruption 8 80.96 Quite High
Pre-term Labor 1 75.00 Quite High
Headache 10 42.48 Quite Low
Ataxia 16 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low
Epilepsy 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data indicate that SK3 channels must be downregulated for the gravid uterus to generate labor contractions sufficient for delivery in both term and preterm mice.
Regulation (downregulated) of SK3 in uterus
1) Confidence 0.45 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 18305226 Disease Relevance 0.25 Pain Relevance 0.10
In conclusion, SK3 channels, in concert with synaptic signals, render the firing pattern of dopaminergic neurons more precise and control the releases of a retrograde messenger.
Regulation (control) of SK3 in dopaminergic neurons
2) Confidence 0.43 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.61
The same factors that prompted the investigations on the possible genetic links between KCNN3 and schizophrenia or bipolar disorder (physiological role of SK3 in neurons, expression pattern of SK3 in brain, polymorphic CAG-repeats in the SK3 amino-terminal region and chromosomal localization of the SK3 gene; see above) led also to studies on its possible involvement in anorexia.
Regulation (pattern) of SK3 in brain associated with manic depressive disorder, anorexia and schizophrenia
3) Confidence 0.23 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.86 Pain Relevance 0

General Comments

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