INT150146

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Context Info
Confidence 0.66
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 0.92
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Kcnn3) cytoplasm (Kcnn3)
Anatomy Link Frequency
erythrocytes 2
neurons 2
blood vessel 1
Golgi cells 1
Kcnn3 (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 16 99.56 Very High Very High Very High
Action potential 80 98.56 Very High Very High Very High
Kinase C 16 91.40 High High
Dopamine 28 79.12 Quite High
Neurotransmitter 8 50.84 Quite High
potassium channel 12 50.00 Quite Low
Pyramidal cell 80 32.96 Quite Low
long-term potentiation 32 31.96 Quite Low
nMDA receptor 36 30.92 Quite Low
Dismenorea 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 17 100.00 Very High Very High Very High
Sickle Cell Anemia 12 97.36 Very High Very High Very High
Volume Depletion And Dehydration 33 96.88 Very High Very High Very High
Hypoxia 30 92.32 High High
Pre-term Labor 1 75.00 Quite High
Increased Venous Pressure Under Development 14 53.04 Quite High
Hyperemia 4 45.68 Quite Low
Death 3 37.04 Quite Low
Disease 62 32.24 Quite Low
Dysmenorrhea 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dopaminergic midbrain neurons express high levels of SK3 mRNA [32, 34, 119] and protein [120].
Positive_regulation (levels) of SK3 in neurons associated with midbrain
1) Confidence 0.66 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.31
Golgi cells express high levels of the SK3 subunit [32].
Positive_regulation (levels) of SK3 subunit in Golgi cells
2) Confidence 0.58 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.08
In a previous study, the overexpression of small conductance calcium-activated K(+) channel isoform 3 in transgenic mice, Kcnn3(tm1Jpad)/Kcnn3(tm1Jpad) (also known as SK3(T/T)), led to compromised parturition, which indicates that KCNN3 (also known as SK3) plays an important role in the delivery process.
Positive_regulation (calcium-activated) of Kcnn3 associated with targeted disruption
3) Confidence 0.50 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 18305226 Disease Relevance 0.17 Pain Relevance 0
In these neurons the SK3 channels are activated by Ca2+ influx triggered by single action potentials and mediate an AHP following each spike [162].
Positive_regulation (activated) of SK3 in neurons associated with action potential
4) Confidence 0.48 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.08
Although the relative contribution of each of these mechanisms and their possible interplay are still somewhat controversial and might depend on the type of blood vessel and stimulation, a considerable consensus has been reached that the initial step of EDHF-dependent relaxation is the activation of SK (in particular SK3) and IK channels in the endothelium (reviewed in [177–179]), as supported also by findings in genetically modified mice overexpressing or lacking SK3 [181] or lacking IK channels [182].
Positive_regulation (activation) of SK3 in blood vessel
5) Confidence 0.39 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.10 Pain Relevance 0
This cation permeability pathway is likely an important source of intracellular Ca2+ for pathologic activation of KCa3.1 in sickle erythrocytes.
Positive_regulation (activation) of KCa3 in erythrocytes
6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2806905 Disease Relevance 0.07 Pain Relevance 0
The deoxygenation-activated conductance is likely responsible for [Ca2+]i elevation in human and mouse sickle cells, leading to activation of KCa3.1 (Gardos channel), with consequent acceleration of pathological sickle cell dehydration.
Positive_regulation (activation) of KCa3 associated with sickle cell anemia and volume depletion and dehydration
7) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806905 Disease Relevance 0.49 Pain Relevance 0
Deoxygenation-induced elevation of [Ca2+]i in mouse sickle erythrocytes did not require KCa3.1 activity.


Neg (not) Positive_regulation (require) of KCa3 in erythrocytes
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2806905 Disease Relevance 0.07 Pain Relevance 0

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