INT150165

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 21
Total Number 24
Disease Relevance 10.10
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (MTTP) transport (MTTP) small molecule metabolic process (MTTP)
Golgi apparatus (MTTP) lipid metabolic process (MTTP)
Anatomy Link Frequency
intestine 2
plasma 1
blood 1
liver 1
MTTP (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 61 92.76 High High
imagery 26 85.24 High High
Pain 11 84.28 Quite High
depression 3 82.20 Quite High
projection neuron 170 80.20 Quite High
tolerance 3 75.52 Quite High
corticosteroid 5 72.32 Quite High
nud 1 68.56 Quite High
IPN 415 11.20 Low Low
Paresthesia 3 7.68 Low Low
Disease Link Frequency Relevance Heat
Chronic Myeloid Leukemia 2 99.84 Very High Very High Very High
Eosinophilia 16 98.94 Very High Very High Very High
Osteogenic Sarcomas 150 98.68 Very High Very High Very High
Cancer 108 98.64 Very High Very High Very High
Cirrhosis 6 97.22 Very High Very High Very High
Hematological Disease 2 93.68 High High
Myeloid Sarcoma 7 91.20 High High
Stress 20 90.44 High High
Disease 101 90.08 High High
Targeted Disruption 30 90.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The overall average expression levels of Abl and GUS were used to normalize the expression levels of the genes of interest.
Gene_expression (levels) of Abl
1) Confidence 0.75 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0 Pain Relevance 0
The overall average expression levels of Abl and GUS were used to normalize the expression levels of the genes of interest.
Gene_expression (expression) of Abl
2) Confidence 0.75 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0 Pain Relevance 0
Imatinib was one of the first successful targeted therapies, initially developed as a specific inhibitor of the bcr-abl kinase aberrantly expressed in chronic myelogenous leukemia.
Gene_expression (expressed) of abl associated with chronic myeloid leukemia
3) Confidence 0.75 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.72 Pain Relevance 0.03
Cirrhosis has been reported in a few cases and one patient required transplantation for hepatic cirrhosis; post transplantation the serum lipoprotein profile increased to normal levels, however the fat absorption defect continued as the mutant MTP remains expressed in the intestine [26].
Gene_expression (expressed) of MTP in intestine associated with cirrhosis
4) Confidence 0.66 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2467409 Disease Relevance 0.48 Pain Relevance 0
Moreover, analysis using AIC revealed that the Ab-L profile can be considered distinct from both L-typical and R-typical profiles (L-typical versus Ab-L: ?
Gene_expression (profile) of Ab-L
5) Confidence 0.65 Published 2008 Journal Neural Develop Section Body Doc Link PMC2292717 Disease Relevance 0 Pain Relevance 0
AICc = 12.92, 99.84% probability that individual fits are correct versus global fit; R-typical versus Ab-L: ?
Gene_expression (typical) of Ab-L
6) Confidence 0.65 Published 2008 Journal Neural Develop Section Body Doc Link PMC2292717 Disease Relevance 0 Pain Relevance 0
Moreover, analysis using AIC revealed that the Ab-L profile can be considered distinct from both L-typical and R-typical profiles (L-typical versus Ab-L: ?
Gene_expression (typical) of Ab-L
7) Confidence 0.65 Published 2008 Journal Neural Develop Section Body Doc Link PMC2292717 Disease Relevance 0 Pain Relevance 0
m; p < 0.01 for Ab-L versus Ab-R) and their processes are tightly confined to the perimeter of the arbor such that the distribution profile of Ab-R axon density is distinct not only from Ab-L arbors but also from wild-type R-typical arbors (Ab-L versus Ab-R: ?
Gene_expression (arbors) of Ab-L
8) Confidence 0.65 Published 2008 Journal Neural Develop Section Body Doc Link PMC2292717 Disease Relevance 0 Pain Relevance 0
These Ab-L arbors extend over a restricted DV depth (20.1 ± 2.9 ?
Gene_expression (arbors) of Ab-L
9) Confidence 0.65 Published 2008 Journal Neural Develop Section Body Doc Link PMC2292717 Disease Relevance 0 Pain Relevance 0.04
As reference genes, Abl and GUS were used.
Gene_expression (used) of Abl
10) Confidence 0.65 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0 Pain Relevance 0
The overall average expression levels of Abl and GUS were used to normalize the expression levels of the genes of interest.
Gene_expression (expression) of Abl
11) Confidence 0.58 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0 Pain Relevance 0
Induction of significant eosinophilia is, in this model, specific for FIP1L1-PDGFRA since expression of another fusion oncogene, p210-BCR/ABL, in the presence of IL-5 over-expression is characterized by a significantly lower eosinophilia than IL-5Tg-F/P recipients.
Gene_expression (expression) of ABL associated with eosinophilia
12) Confidence 0.58 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 1.65 Pain Relevance 0.04
Peripheral blood RT-PCR for bcr-abl was negative.
Neg (negative) Gene_expression (negative) of abl in blood
13) Confidence 0.58 Published 2008 Journal Leuk. Res. Section Abstract Doc Link 18308388 Disease Relevance 1.50 Pain Relevance 0.13
The MTP molecule is predicted to consist of three major structural domains: N-terminal ?
Gene_expression (molecule) of MTP
14) Confidence 0.57 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2467409 Disease Relevance 0.25 Pain Relevance 0
In 1993, the region on chromosome 4q22-24 that encodes the large subunit of MTP was cloned and sequenced, and human MTP mutations in ABL patients were reported [5].
Gene_expression (mutations) of MTP
15) Confidence 0.57 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2467409 Disease Relevance 0.58 Pain Relevance 0
Because of this, we speculate that due to MTP inhibition, less TG were transferred to the chylomicron particle being packaged in the intestine.
Gene_expression (transferred) of MTP in intestine
16) Confidence 0.23 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1262701 Disease Relevance 0.06 Pain Relevance 0
Further evidence was obtained from a cell culture study in which researchers [28] proved that MTP is limiting in the production of apo B containing lipoproteins.
Gene_expression (limiting) of MTP
17) Confidence 0.23 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1262701 Disease Relevance 0.35 Pain Relevance 0
MTP is involved in intracellular lipid transport and secretion, and is primarily expressed in liver and intestinal tissues [16].
Gene_expression (expressed) of MTP in liver
18) Confidence 0.20 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.18 Pain Relevance 0
The microarray results showed that the expression of the gene encoding MTP (probeset 205675_at on the Affymetrix U113A microarray and indicated by UniGene reference Hs.195799) was increased by 19.3%, as a result of the exposure to L. plantarum.
Gene_expression (expression) of MTP
19) Confidence 0.20 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0 Pain Relevance 0
The fatty acid binding protein FABP1 was upregulated in the 6-h exposure study, as was the microsomal and ER-localized triglyceride transfer protein, MTP, which is discussed in more detail below.
Gene_expression (microsomal) of ER-localized triglyceride transfer protein
20) Confidence 0.20 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.33 Pain Relevance 0

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