INT150168

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.16
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SLC6A4) endosome (SLC6A4) plasma membrane (SLC6A4)
SLC6A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 2 97.76 Very High Very High Very High
sSRI 1 96.08 Very High Very High Very High
depression 2 90.48 High High
Serotonin 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Depression 2 90.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The levels of MAPK phosphorylation, 5-HTT mRNA expression and 5-HT uptake all increased in the IFN-alpha-treated cells but were blocked in those that were pretreated with MAPK inhibitors and fluoxetine.
Negative_regulation (blocked) of Transcription (expression) of 5-HTT associated with fluoxetine
1) Confidence 0.42 Published 2008 Journal J. Psychopharmacol. (Oxford) Section Abstract Doc Link 18308792 Disease Relevance 0.16 Pain Relevance 0.47

General Comments

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