INT150217

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 4.41
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (TNFSF13B) signal transduction (TNFSF13B) extracellular space (TNFSF13B)
extracellular region (TNFSF13B) plasma membrane (TNFSF13B)
Anatomy Link Frequency
B cell 1
TNFSF13B (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 11 100.00 Very High Very High Very High
rheumatoid arthritis 21 98.72 Very High Very High Very High
cINOD 6 94.56 High High
dexamethasone 8 86.48 High High
antagonist 25 76.68 Quite High
Angina 15 5.00 Very Low Very Low Very Low
methotrexate 10 5.00 Very Low Very Low Very Low
headache 10 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
withdrawal 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 21 98.72 Very High Very High Very High
Systemic Lupus Erythematosus 250 94.92 High High
INFLAMMATION 11 94.16 High High
Disease 130 92.60 High High
Necrosis 10 92.32 High High
Cancer 10 91.96 High High
Proteinuria 5 78.76 Quite High
Renal Disease 20 74.24 Quite High
Hypergammaglobulinemia 5 72.28 Quite High
Targeted Disruption 5 67.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The antibody exerts its biologic activity by preventing the binding of BLyS to its receptors [19].
BLyS Binding (binding) of
1) Confidence 0.30 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 0.84 Pain Relevance 0.04
mAb that binds to soluble BLyS with high affinity.
BLyS Binding (binds) of
2) Confidence 0.30 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 0.89 Pain Relevance 0.04
Europium-labeled BLyS binding was quantitated by time-resolved fluorometric spectroscopy at 615 nm (excitation at 340 nm).
BLyS Binding (binding) of
3) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 0.46 Pain Relevance 0
BLyS exists in both membrane-bound and soluble forms.
BLyS Binding (bound) of
4) Confidence 0.23 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 0.95 Pain Relevance 0.05
Anti-belimumab antibody present in the sample would bind to the immobilized belimumab, and competitively inhibit binding of europium-labeled BLyS.
BLyS Binding (binding) of
5) Confidence 0.22 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 0.44 Pain Relevance 0
FLS isolated from patients with RA (FLS-RA) express B cell-activating factor belonging to the TNF family (BAFF), a cytokine that has been associated with the onset and progression of RA.
BAFF Binding (associated) of in B cell associated with rheumatoid arthritis and cytokine
6) Confidence 0.05 Published 2008 Journal Cytokine Section Abstract Doc Link 18316202 Disease Relevance 0.83 Pain Relevance 0.72

General Comments

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