INT150219

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 5.91
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (TNFSF13B) signal transduction (TNFSF13B) extracellular space (TNFSF13B)
extracellular region (TNFSF13B) plasma membrane (TNFSF13B)
Anatomy Link Frequency
macrophages 1
granulocyte 1
monocytes 1
lymphocyte 1
dendritic cells 1
TNFSF13B (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 11 100.00 Very High Very High Very High
dexamethasone 8 99.70 Very High Very High Very High
rheumatoid arthritis 21 90.72 High High
cINOD 6 83.68 Quite High
antagonist 25 66.96 Quite High
Angina 15 5.00 Very Low Very Low Very Low
methotrexate 10 5.00 Very Low Very Low Very Low
headache 10 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
withdrawal 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 10 100.00 Very High Very High Very High
Cancer 10 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 250 98.92 Very High Very High Very High
Disease 130 92.00 High High
Rheumatoid Arthritis 21 90.72 High High
Targeted Disruption 5 84.56 Quite High
INFLAMMATION 11 83.44 Quite High
Hypergammaglobulinemia 5 76.72 Quite High
Renal Disease 20 72.48 Quite High
Autoimmune Disease 5 66.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B-lymphocyte stimulator (BLyS) is a member of the tumor necrosis factor (TNF) ligand superfamily of cytokines that is expressed and secreted by monocytes, macrophages, dendritic cells, and granulocyte colony-stimulating factor activated neutrophils [5,6].
Localization (secreted) of BLyS in dendritic cells associated with necrosis, cancer and cytokine
1) Confidence 0.47 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 1.00 Pain Relevance 0.05
The biologically active, soluble form of BLyS is enzymatically cleaved from the cell membrane and can bind to any of three receptors: TACI (transmembrane activator and calcium-modulator and cyclophilin ligand interactor) [7]; BCMA (B-cell Maturation Antigen) [8]; and BAFF-R (B-cell lymphocyte activating factor receptor)/BLyS receptor 3 [9,10], localized primarily on B lymphocytes.
Localization (localized) of BLyS in lymphocyte
2) Confidence 0.44 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 1.04 Pain Relevance 0.07
B-lymphocyte stimulator (BLyS) is a member of the tumor necrosis factor (TNF) ligand superfamily of cytokines that is expressed and secreted by monocytes, macrophages, dendritic cells, and granulocyte colony-stimulating factor activated neutrophils [5,6].
Localization (secreted) of BLyS in monocytes associated with necrosis, cancer and cytokine
3) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 1.00 Pain Relevance 0.05
B-lymphocyte stimulator (BLyS) is a member of the tumor necrosis factor (TNF) ligand superfamily of cytokines that is expressed and secreted by monocytes, macrophages, dendritic cells, and granulocyte colony-stimulating factor activated neutrophils [5,6].
Localization (secreted) of BLyS in granulocyte associated with necrosis, cancer and cytokine
4) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 1.00 Pain Relevance 0.05
B-lymphocyte stimulator (BLyS) is a member of the tumor necrosis factor (TNF) ligand superfamily of cytokines that is expressed and secreted by monocytes, macrophages, dendritic cells, and granulocyte colony-stimulating factor activated neutrophils [5,6].
Localization (secreted) of BLyS in macrophages associated with necrosis, cancer and cytokine
5) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 1.00 Pain Relevance 0.05
Also, Dex inhibited the secretion of BAFF in a time-dependent manner reaching 76% of inhibition 72 h after treatment.
Localization (secretion) of BAFF associated with dexamethasone
6) Confidence 0.09 Published 2008 Journal Cytokine Section Abstract Doc Link 18316202 Disease Relevance 0.86 Pain Relevance 0.88

General Comments

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