INT150223

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Context Info
Confidence 0.21
First Reported 2007
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 3.44
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (TNFSF13B) signal transduction (TNFSF13B) extracellular space (TNFSF13B)
extracellular region (TNFSF13B) plasma membrane (TNFSF13B)
TNFSF13B (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 16 100.00 Very High Very High Very High
rheumatoid arthritis 26 99.68 Very High Very High Very High
cINOD 2 97.28 Very High Very High Very High
cytokine 4 92.64 High High
Inflammation 1 83.36 Quite High
chemokine 1 60.52 Quite High
Infliximab 4 5.00 Very Low Very Low Very Low
Etanercept 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Adalimumab 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 8 99.76 Very High Very High Very High
Rheumatoid Arthritis 26 99.68 Very High Very High Very High
Disease Progression 1 99.28 Very High Very High Very High
INFLAMMATION 3 97.04 Very High Very High Very High
B-cell Lymphoma 3 94.08 High High
Malignant Neoplastic Disease 3 93.44 High High
Syndrome 30 92.36 High High
Targeted Disruption 1 91.52 High High
Attention Deficit Hyperactivity Disorder 2 91.16 High High
Hypergammaglobulinemia 2 86.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dysregulated BAFF expression is implicated in disease progression and perpetuation of humoral autoimmunity.
Regulation (Dysregulated) of Gene_expression (expression) of BAFF associated with autoimmune disease and disease progression
1) Confidence 0.21 Published 2007 Journal Clin Rev Allergy Immunol Section Body Doc Link PMC2071970 Disease Relevance 1.68 Pain Relevance 0.11
In the present study, we examined the effect of dexamethasone (Dex) on constitutive and TNF-alpha- and IFN-gamma-induced BAFF expression in FLS-RA.
Spec (examined) Regulation (effect) of Gene_expression (expression) of BAFF associated with rheumatoid arthritis and dexamethasone
2) Confidence 0.06 Published 2008 Journal Cytokine Section Abstract Doc Link 18316202 Disease Relevance 0.93 Pain Relevance 0.82
Moreover, Dex suppressed both mRNA and protein BAFF expression induced by TNF-alpha but had no effect on IFN-gamma-induced BAFF expression.
Neg (no) Regulation (effect) of Gene_expression (expression) of BAFF associated with dexamethasone
3) Confidence 0.05 Published 2008 Journal Cytokine Section Abstract Doc Link 18316202 Disease Relevance 0.84 Pain Relevance 0.87

General Comments

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