INT150248

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.68
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ido1) oxidoreductase activity (Ido1) cytoplasm (Ido1)
Anatomy Link Frequency
oral mucosa 2
Ido1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Analgesic 34 99.46 Very High Very High Very High
Pain 53 94.64 High High
withdrawal 56 89.04 High High
Paracetamol 46 82.44 Quite High
antagonist 2 76.52 Quite High
nociceptor 2 52.40 Quite High
Pain score 19 38.60 Quite Low
allodynia 1 35.28 Quite Low
Hyperalgesia 1 20.60 Low Low
c fibre 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Overdose 136 100.00 Very High Very High Very High
Overactive Bladder 29 100.00 Very High Very High Very High
Bladder Disease 40 95.12 Very High Very High Very High
Pain 52 89.04 High High
Suicidal Behaviour 28 87.92 High High
Poisoning 6 63.92 Quite High
Canker Sores 4 50.00 Quite Low
Hypersensitivity 1 50.00 Quite Low
Neuropathic Pain 1 35.28 Quite Low
Hyperalgesia 1 20.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased availability of the other prescription compound analgesics resulted in a significant increase in the rate of IDO presentations to hospital involving these drugs.
Positive_regulation (increase) of Gene_expression (presentations) of IDO associated with analgesic and overdose
1) Confidence 0.43 Published 2010 Journal BMC Clin Pharmacol Section Body Doc Link PMC2858125 Disease Relevance 0.63 Pain Relevance 0.51
However, the magnitude of the decrease in distalgesic-related IDO presentations was about five times greater than the magnitude of the increase in IDO presentations involving the other prescription compound analgesics.
Positive_regulation (increase) of Gene_expression (presentations) of IDO associated with analgesic and overdose
2) Confidence 0.43 Published 2010 Journal BMC Clin Pharmacol Section Body Doc Link PMC2858125 Disease Relevance 0.67 Pain Relevance 0.56
CONCLUSIONS: These findings suggest that CD4(+)CD25(high) Treg cells are both functionally and quantitatively compromised in RAS and that decreased constitutive expression of IDO in oral mucosa in RAS may lead to the loss of local immune tolerance.


Spec (may) Positive_regulation (lead) of Gene_expression (expression) of IDO in oral mucosa
3) Confidence 0.06 Published 2008 Journal J. Oral Pathol. Med. Section Body Doc Link 18318707 Disease Relevance 0 Pain Relevance 0
IDO : Idiopathic detrusor overactivity
Positive_regulation (overactivity) of Gene_expression (overactivity) of IDO associated with overactive bladder
4) Confidence 0.04 Published 2006 Journal BMC Urol Section Body Doc Link PMC1766360 Disease Relevance 1.38 Pain Relevance 0.70

General Comments

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