INT150248

Context Info Confidence 0.43 First Reported 2006 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 2 Total Number 4 Disease Relevance 2.68 Pain Relevance 1.77

cytosol (Ido1) oxidoreductase activity (Ido1) cytoplasm (Ido1)

Anatomy Link Frequency oral mucosa 2 Ido1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Analgesic 34 99.46 Pain 53 94.64 withdrawal 56 89.04 Paracetamol 46 82.44 antagonist 2 76.52 nociceptor 2 52.40 Pain score 19 38.60 allodynia 1 35.28 Hyperalgesia 1 20.60 c fibre 5 5.00

Disease Link Frequency Relevance Heat Overdose 136 100.00 Overactive Bladder 29 100.00 Bladder Disease 40 95.12 Pain 52 89.04 Suicidal Behaviour 28 87.92 Poisoning 6 63.92 Canker Sores 4 50.00 Hypersensitivity 1 50.00 Neuropathic Pain 1 35.28 Hyperalgesia 1 20.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The increased availability of the other prescription compound analgesics resulted in a significant increase in the rate of IDO presentations to hospital involving these drugs.

Positive_regulation (increase) of Gene_expression (presentations) of IDO associated with analgesic and overdose

1) Confidence 0.43 Published 2010 Journal BMC Clin Pharmacol Section Body Doc Link PMC2858125 Disease Relevance 0.63 Pain Relevance 0.51

However, the magnitude of the decrease in distalgesic-related IDO presentations was about five times greater than the magnitude of the increase in IDO presentations involving the other prescription compound analgesics.

Positive_regulation (increase) of Gene_expression (presentations) of IDO associated with analgesic and overdose

2) Confidence 0.43 Published 2010 Journal BMC Clin Pharmacol Section Body Doc Link PMC2858125 Disease Relevance 0.67 Pain Relevance 0.56

CONCLUSIONS: These findings suggest that CD4(+)CD25(high) Treg cells are both functionally and quantitatively compromised in RAS and that decreased constitutive expression of IDO in oral mucosa in RAS may lead to the loss of local immune tolerance.

Spec (may) Positive_regulation (lead) of Gene_expression (expression) of IDO in oral mucosa

3) Confidence 0.06 Published 2008 Journal J. Oral Pathol. Med. Section Body Doc Link 18318707 Disease Relevance 0 Pain Relevance 0

IDO : Idiopathic detrusor overactivity

Positive_regulation (overactivity) of Gene_expression (overactivity) of IDO associated with overactive bladder

4) Confidence 0.04 Published 2006 Journal BMC Urol Section Body Doc Link PMC1766360 Disease Relevance 1.38 Pain Relevance 0.70

General Comments

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