INT150251

Context Info Confidence 0.61 First Reported 2007 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 7 Total Number 7 Disease Relevance 0.43 Pain Relevance 0.76

growth (FOXP3) nucleus (FOXP3) intracellular (FOXP3) embryo development (FOXP3) protein complex (FOXP3) cytoplasm (FOXP3)

Anatomy Link Frequency regulatory T cell 1 oral mucosa 1 FOXP3 (Homo sapiens)

Pain Link Frequency Relevance Heat tolerance 37 92.76 Inflammation 46 90.64 cytokine 45 89.60 rheumatoid arthritis 76 80.80 abatacept 9 80.40 Osteoarthritis 25 5.00 cva 6 5.00 fibrosis 6 5.00 withdrawal 4 5.00 psoriasis 4 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 45 90.64 Rheumatoid Arthritis 77 80.80 Arthritis 2 54.16 Canker Sores 8 50.00 Apoptosis 7 46.20 Cancer 45 37.84 Colon Cancer 4 37.20 Autoimmune Disease 12 29.20 Syndrome 2 21.36 Viral Infection 2 20.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Moreover, levels of FOXP3 mRNA were significantly higher in the group with successful reversal of acute rejection than in the group without reversal.

Transcription (levels) of FOXP3

1) Confidence 0.61 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0 Pain Relevance 0.15

The patients in higher third of FOXP3 mRNA level had the lowest rate of graft failure following an acute rejection episode.

Transcription (level) of FOXP3

2) Confidence 0.61 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0 Pain Relevance 0.13

Muthukumar et al (2005) found that urinary levels of FOXP3 mRNA, a functional factor specific to T-regs, were inversely correlated with serum creatinine at the time of acute rejection.

Transcription (levels) of FOXP3

3) Confidence 0.45 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0 Pain Relevance 0.16

Moreover it has been demonstrated that a substantial percentage of Tregs had transient or unstable expression of the transcription factor FoxP3.

Transcription (transcription) of factor FoxP3

4) Confidence 0.39 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.09 Pain Relevance 0.17

Foxp3 is the transcription factor controlling regulatory T cell development[37], while, ROR?

Transcription (transcription) of Foxp3 in regulatory T cell

5) Confidence 0.32 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2950393 Disease Relevance 0.34 Pain Relevance 0.14

We failed to detect FOXP3 mRNA, while IDO mRNA expression was decreased in non-lesional mucosa biopsies from RAS patients compared with ulcer biopsies or normal mucosa from healthy donors.

Neg (failed) Transcription (detect) of FOXP3

6) Confidence 0.11 Published 2008 Journal J. Oral Pathol. Med. Section Body Doc Link 18318707 Disease Relevance 0 Pain Relevance 0

We also attempted to detect the presence of FOXP3 and indoleamine 2,3-dioxygenase (IDO) mRNA in the lesional and non-lesional oral mucosa of RAS patients and healthy individuals using real-time PCR assay.

Transcription (presence) of FOXP3 in oral mucosa

7) Confidence 0.11 Published 2008 Journal J. Oral Pathol. Med. Section Body Doc Link 18318707 Disease Relevance 0 Pain Relevance 0

General Comments

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