INT15026

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Context Info
Confidence 0.36
First Reported 1983
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 26
Total Number 26
Disease Relevance 3.76
Pain Relevance 10.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 4
spikes 2
descending colon 2
brain 2
reticulum 2
NA (Homo sapiens)
Pain Link Frequency Relevance Heat
noradrenaline 33 100.00 Very High Very High Very High
Dopamine 14 100.00 Very High Very High Very High
Desipramine 8 100.00 Very High Very High Very High
Nicotine 4 100.00 Very High Very High Very High
Clonidine 1 100.00 Very High Very High Very High
Glutamate 1 100.00 Very High Very High Very High
Gabapentin 40 99.98 Very High Very High Very High
tetrodotoxin 35 99.74 Very High Very High Very High
antidepressant 7 99.68 Very High Very High Very High
Lamotrigine 8 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Gallstones 4 99.68 Very High Very High Very High
Stress Incontinence 4 98.80 Very High Very High Very High
Death 4 98.44 Very High Very High Very High
INFLAMMATION 10 97.12 Very High Very High Very High
Diarrhoea 7 97.12 Very High Very High Very High
Weight Gain 2 96.60 Very High Very High Very High
Stress 70 87.20 High High
Increased Venous Pressure Under Development 3 82.72 Quite High
Diabetes Mellitus 1 79.36 Quite High
Hypertension 4 78.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In model A, addition of 5.0 g/L TX to ORS reversed Na+ secretion and improved net water as well as K+ and glucose absorption, compared with THEO-treated rats perfused with ORS without TX.
Negative_regulation (reversed) of Localization (secretion) of Na
1) Confidence 0.36 Published 1999 Journal Pediatr. Res. Section Abstract Doc Link 10088661 Disease Relevance 0.53 Pain Relevance 0.07
Long-term antidepressant administration reduces the inhibitory influence of clonidine and HT on presynaptic release of 14C-NA and 3H-HT by brain slices.
Negative_regulation (reduces) of Localization (release) of NA in brain associated with antidepressant and clonidine
2) Confidence 0.36 Published 1986 Journal Biull Eksp Biol Med Section Abstract Doc Link 3708140 Disease Relevance 0 Pain Relevance 0.45
Class I antiarrhythmics inhibit Na+ absorption and Cl- secretion in rabbit descending colon epithelium.
Negative_regulation (inhibit) of Localization (secretion) of Na in descending colon
3) Confidence 0.31 Published 2005 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 16012869 Disease Relevance 0.10 Pain Relevance 0.28
By contrast, the species-specific suppressor from M. pinodes inhibited the elicitor-induced release of Na+ and K+ ions from pea tissues, but, conversely, by itself it elicited either the defense response or the release of Na+ and K+ ions from cowpea tissues.
Negative_regulation (inhibited) of Localization (release) of Na
4) Confidence 0.27 Published 1997 Journal Plant Cell Physiol. Section Abstract Doc Link 9249987 Disease Relevance 0 Pain Relevance 0.07
The ability to induce biliary secretion of Na+ and Cl- also decreased when Cl- was replaced by NO3- or isethionate and when Na+ was replaced by Li+, respectively.
Negative_regulation (decreased) of Localization (secretion) of Na
5) Confidence 0.16 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6842392 Disease Relevance 0.13 Pain Relevance 0.03
Biliary secretion of Na+ or Cl- declined during cholestasis and increased during choleresis.
Negative_regulation (declined) of Localization (secretion) of Na associated with gallstones
6) Confidence 0.16 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6842392 Disease Relevance 0.17 Pain Relevance 0.14
These findings suggest that GBP inhibits K+-evoked [3H]-NA release through activation of KATP channels.
Negative_regulation (inhibits) of Localization (release) of NA associated with gabapentin
7) Confidence 0.14 Published 2001 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11383714 Disease Relevance 0 Pain Relevance 0.94
GBP decreased [3H]-NA release from rat hippocampal with a pIC50 of 5.59 and a maximum inhibition of 44%.
Negative_regulation (decreased) of Localization (release) of NA associated with gabapentin
8) Confidence 0.14 Published 2001 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11383714 Disease Relevance 0 Pain Relevance 0.78
Although phenytoin (10 microM), carbamazepine (100 microM) and lamotrigine (10 microM) also decreased [3H]-NA release (by 25%, 57% and 22%, respectively), glibenclamide did not antagonize the effects of these classical Na+ channel blockers.
Negative_regulation (decreased) of Localization (release) of NA associated with lamotrigine and carbamazepine
9) Confidence 0.14 Published 2001 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11383714 Disease Relevance 0 Pain Relevance 1.01
The KATP channel opener pinacidil (10 microM), like GBP, decreased [3H]-NA release from rat hippocampal slices by 27% and this effect was also antagonized by glibenclamide.
Negative_regulation (decreased) of Localization (release) of NA associated with gabapentin
10) Confidence 0.14 Published 2001 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11383714 Disease Relevance 0 Pain Relevance 0.86
With each dose of each NSAID, inulin and paraaminohippurate (PAH) clearances and fractional excretion of NA+ decreased.
Negative_regulation (decreased) of Localization (excretion) of NA associated with cinod
11) Confidence 0.13 Published 1986 Journal Am. J. Kidney Dis. Section Abstract Doc Link 2947456 Disease Relevance 0.76 Pain Relevance 0.37
Carbachol (8 nmol) reduced urinary volume and increased Na+ excretion.
Negative_regulation (reduced) of Localization (excretion) of Na
12) Confidence 0.07 Published 1990 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 1966129 Disease Relevance 0 Pain Relevance 0.33
60 mV, peaks around 0 mV and subsequently decreases due to reduced Na+ driving force (Fig. 2c).
Negative_regulation (reduced) of Localization (force) of Na
13) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013114 Disease Relevance 0 Pain Relevance 0.21
INaL is more sensitive to flecainide than INa, such that abnormal Na+ entry via INaL can be inhibited at drug concentrations that have almost no effect on peak INa.58
Negative_regulation (inhibited) of Localization (entry) of Na
14) Confidence 0.05 Published 2011 Journal Europace Section Body Doc Link PMC3024037 Disease Relevance 0.70 Pain Relevance 0.07
Tetrodotoxin (TTX) was used to block Na+ spikes and synaptic transmitter release.
Negative_regulation (block) of Localization (release) of Na in spikes associated with tetrodotoxin
15) Confidence 0.05 Published 1990 Journal Brain Res. Section Abstract Doc Link 1973065 Disease Relevance 0 Pain Relevance 0.52
After stimulation with CT, TTX significantly inhibited Na+ and Cl- secretion (delta JNa+ = 2.15 +/- 0.61 and delta JCl- = 2.15 +/- 0.76 microEq.hr-1.cm-2; P less than 0.01).
Negative_regulation (inhibited) of Localization (secretion) of Na associated with tetrodotoxin
16) Confidence 0.04 Published 1991 Journal J. Physiol. (Paris) Section Abstract Doc Link 1820451 Disease Relevance 0.14 Pain Relevance 0.66
Similarly, HXM significantly inhibited CT-stimulated Na+ and Cl- secretion (delta JNa+ = 1.73 +/- 0.70 and delta JCl- = 1.46 +/- 0.62 microEq.hr-1.cm-2; P less than 0.02). 3) In TTX and HXM treated tissues there was no difference in the increase in Isc caused by cAMP (2 x 10(-3) M), calcium ionophore A 23187 (4 x 10(-6) M) and glucose (10(-3) M) compared to the untreated tissues in the presence or absence of CT.
Negative_regulation (inhibited) of Localization (secretion) of Na associated with tetrodotoxin
17) Confidence 0.04 Published 1991 Journal J. Physiol. (Paris) Section Abstract Doc Link 1820451 Disease Relevance 0.14 Pain Relevance 0.64
Therefore, it would be beneficial to decrease the release of Na+ into the surrounding tissue.
Negative_regulation (decrease) of Localization (release) of Na
18) Confidence 0.04 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2871132 Disease Relevance 0.62 Pain Relevance 0.05
Moreover, in the absence of extracellular Ca2+, both the 3,4-DAP-evoked [3H]NA release and the facilitatory effect of 4 beta-PDB were abolished in the presence of tetrodotoxin or in the absence of Na+ in the superfusion medium.
Negative_regulation (abolished) of Localization (release) of NA associated with tetrodotoxin
19) Confidence 0.04 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1713165 Disease Relevance 0 Pain Relevance 0.42
Metal-evoked [(3)H]NA release did not increase in the absence of desipramine and was completely blocked by reserpine preincubation, indicating a vesicular origin of [(3)H]NA release but not a mechanism involving reversal of the transmitter transporter.
Negative_regulation (blocked) of Localization (release) of NA associated with desipramine
20) Confidence 0.02 Published 2000 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 10652247 Disease Relevance 0 Pain Relevance 0.25

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