INT15027

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Context Info
Confidence 0.26
First Reported 1983
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 3.40
Pain Relevance 2.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neural 2
NA (Homo sapiens)
Pain Link Frequency Relevance Heat
noradrenaline 20 100.00 Very High Very High Very High
Dopamine 14 100.00 Very High Very High Very High
Desipramine 1 99.24 Very High Very High Very High
narcan 2 97.12 Very High Very High Very High
Action potential 27 96.48 Very High Very High Very High
tetrodotoxin 5 95.24 Very High Very High Very High
antagonist 1 94.76 High High
agonist 1 92.68 High High
Bile 2 91.08 High High
opiate 3 86.08 High High
Disease Link Frequency Relevance Heat
Gallstones 2 100.00 Very High Very High Very High
Stress Incontinence 4 96.68 Very High Very High Very High
Stress 16 87.56 High High
Toxicity 18 86.96 High High
Increased Venous Pressure Under Development 9 85.56 High High
Hepatotoxicity 6 83.32 Quite High
Diuresis 28 81.92 Quite High
Polyuria 2 71.56 Quite High
Overactive Bladder 6 70.08 Quite High
Injury 9 69.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most obvious effect of the mutation is an increase in late Na+ channel current over a broad range of cellular membrane potentials, an effect similar to other previously-described LQT-3 mutations such as the ?
Positive_regulation (increase) of Localization (current) of Na
1) Confidence 0.26 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2082660 Disease Relevance 0 Pain Relevance 0.17
Biliary secretion of Na+ or Cl- declined during cholestasis and increased during choleresis.
Positive_regulation (increased) of Localization (secretion) of Na associated with gallstones
2) Confidence 0.18 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6842392 Disease Relevance 0.17 Pain Relevance 0.14
binding sites, and increasing the excretion of Na+ by inhibiting Na+ re-absorption.[25] Furthermore, like other thiazide diuretics,[26] BTI did not alter urinary Ca2+ level.
Positive_regulation (increasing) of Localization (excretion) of Na
3) Confidence 0.13 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2992138 Disease Relevance 0.15 Pain Relevance 0
In conclusion, this study shows for the first time, that BTI of Sri Lankan BOPF grade black tea manufactured from Camellia sinensis L. plant possesses pharmacologically safe, mild oral diuretic activity, which is mediated via multiple mechanisms: increased urinary Na+ output, inhibition of aldosterone secretion, inhibition of carbonic anhydrase activity, and through thiazide-like diuretic action.
Positive_regulation (increased) of Localization (secretion) of Na
4) Confidence 0.09 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2992138 Disease Relevance 0.47 Pain Relevance 0
Carbachol (8 nmol) reduced urinary volume and increased Na+ excretion.
Positive_regulation (increased) of Localization (excretion) of Na
5) Confidence 0.08 Published 1990 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 1966129 Disease Relevance 0 Pain Relevance 0.33
INaL is more sensitive to flecainide than INa, such that abnormal Na+ entry via INaL can be inhibited at drug concentrations that have almost no effect on peak INa.58
Positive_regulation (concentrations) of Localization (entry) of Na
6) Confidence 0.06 Published 2011 Journal Europace Section Body Doc Link PMC3024037 Disease Relevance 0.71 Pain Relevance 0.08
INaL is more sensitive to flecainide than INa, such that abnormal Na+ entry via INaL can be inhibited at drug concentrations that have almost no effect on peak INa.58
Positive_regulation (via) of Localization (entry) of Na
7) Confidence 0.06 Published 2011 Journal Europace Section Body Doc Link PMC3024037 Disease Relevance 0.69 Pain Relevance 0.07
INaL is more sensitive to flecainide than INa, such that abnormal Na+ entry via INaL can be inhibited at drug concentrations that have almost no effect on peak INa.58
Positive_regulation (abnormal) of Localization (entry) of Na
8) Confidence 0.06 Published 2011 Journal Europace Section Body Doc Link PMC3024037 Disease Relevance 0.69 Pain Relevance 0.07
Ruthenium red, a blocker of mitochondrial Ca2+ reuptake, potently increased 3,4-DAP-evoked [3H]NA release in Ca(2+)-free EGTA-containing medium.
Positive_regulation (increased) of Localization (release) of NA
9) Confidence 0.04 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1713165 Disease Relevance 0 Pain Relevance 0.42
Indeed, Traub and Miles suggested that the failure of those models may be due to the insufficiently accurate representation of Na+ or low-voltage-activated Ca2+ currents [4].


Positive_regulation (activated) of Localization (representation) of Na
10) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2323611 Disease Relevance 0.06 Pain Relevance 0.09
Metal-evoked [(3)H]NA release did not increase in the absence of desipramine and was completely blocked by reserpine preincubation, indicating a vesicular origin of [(3)H]NA release but not a mechanism involving reversal of the transmitter transporter.
Neg (not) Positive_regulation (increase) of Localization (release) of NA associated with desipramine
11) Confidence 0.02 Published 2000 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 10652247 Disease Relevance 0 Pain Relevance 0.21
Castration or L-NOARG had no effect on the electrically induced release of 3H-NA in either of the urethral tissues.
Positive_regulation (induced) of Localization (release) of NA associated with noradrenaline
12) Confidence 0.02 Published 1994 Journal J. Urol. Section Abstract Doc Link 8051724 Disease Relevance 0.30 Pain Relevance 0.37
After in-vivo i.v. administration of [3H]DA, the glomerulosa content of DA and NA and the in-vitro release of [3H]DA and [3H]NA of zona glomerulosa both increased, indicating that the local varicose axon terminals were able to accumulate DA from the circulation, convert it into NA and release it in response to neural activity.
Positive_regulation (increased) of Localization (release) of NA in neural associated with dopamine and noradrenaline
13) Confidence 0.01 Published 1993 Journal J. Endocrinol. Section Abstract Doc Link 8308458 Disease Relevance 0.16 Pain Relevance 1.02

General Comments

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