INT150285

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 10.22
Pain Relevance 11.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Efnb1) nucleus (Efnb1) cytoplasm (Efnb1)
Anatomy Link Frequency
DRG 6
spinal 1
spinal cord 1
Efnb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nociceptor 16 100.00 Very High Very High Very High
Sciatica 10 100.00 Very High Very High Very High
dorsal rhizotomy 43 99.98 Very High Very High Very High
Spinal cord 130 99.84 Very High Very High Very High
dorsal root ganglion 53 99.84 Very High Very High Very High
Eae 60 99.82 Very High Very High Very High
spinal dorsal horn 15 98.76 Very High Very High Very High
Dorsal horn 33 98.36 Very High Very High Very High
hyperexcitability 6 98.24 Very High Very High Very High
Dorsal horn neuron 23 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 65 99.84 Very High Very High Very High
Injury 45 99.82 Very High Very High Very High
Nociception 47 99.40 Very High Very High Very High
Neuropathic Pain 59 98.96 Very High Very High Very High
Nervous System Injury 19 98.08 Very High Very High Very High
Hyperalgesia 80 93.36 High High
Pain 44 88.36 High High
Inflammatory Pain 21 69.12 Quite High
INFLAMMATION 27 50.00 Quite Low
Targeted Disruption 6 47.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings indicate that ephrinB-EphB receptor activation and redistribution in DRG and DH neurons after nerve injury could contribute to neuropathic pain.
Positive_regulation (activation) of ephrinB in DRG associated with dorsal root ganglion, nervous system injury, spinal dorsal horn and neuropathic pain
1) Confidence 0.29 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18321739 Disease Relevance 1.74 Pain Relevance 1.82
Upregulation and redistribution of ephrinB and EphB receptor in dorsal root ganglion and spinal dorsal horn neurons after peripheral nerve injury and dorsal rhizotomy.
Positive_regulation (Upregulation) of ephrinB in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, nervous system injury, dorsal rhizotomy, nociceptor, dorsal horn neuron and peripheral nerve injury
2) Confidence 0.29 Published 2008 Journal Eur J Pain Section Title Doc Link 18321739 Disease Relevance 1.04 Pain Relevance 1.42
DR suppressed CCI-induced upregulation of ephrinB1 in SC and EphB1 receptor in DRG and SC.
Positive_regulation (upregulation) of ephrinB1 in DRG associated with dorsal root ganglion, dorsal rhizotomy, eae and spinal cord
3) Confidence 0.29 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18321739 Disease Relevance 1.51 Pain Relevance 1.85
DR increases ephrinB1 in DRG, not SC and EphB receptor in SC, not DRG.
Neg (not) Positive_regulation (increases) of ephrinB1 in DRG associated with dorsal root ganglion, dorsal rhizotomy and spinal cord
4) Confidence 0.17 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18321739 Disease Relevance 1.55 Pain Relevance 1.85
Upregulation and redistribution of ephrinB and EphB receptor in dorsal root ganglion and spinal dorsal horn neurons after peripheral nerve injury and dorsal rhizotomy.
Positive_regulation (Upregulation) of ephrinB in spinal associated with ganglion cysts, dorsal root ganglion, nervous system injury, dorsal rhizotomy, nociceptor, dorsal horn neuron and peripheral nerve injury
5) Confidence 0.10 Published 2008 Journal Eur J Pain Section Title Doc Link 18321739 Disease Relevance 1.04 Pain Relevance 1.42
Their findings, including a significant upregulation of ephrinB1 and EphB1 in the spinal cord and dorsal root ganglia of adult rat after chronic constriction injury, which was time dependent and correlated with the development of thermal hyperalgesia, support the hypothesis of an involvement of this system in the onset of neuropathic pain.
Positive_regulation (upregulation) of ephrinB1 in spinal cord associated with thermal hyperalgesia, eae, injury, neuropathic pain and spinal cord
6) Confidence 0.01 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.97 Pain Relevance 0.99
In the same model, activation of EphB receptors with ephrinB-Fc in isolated dorsal root ganglia induced hyperexcitability of small nociceptive neurons, but only in injured animals.
Positive_regulation (activation) of ephrinB in dorsal root ganglia associated with nociception and hyperexcitability
7) Confidence 0.01 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 1.39 Pain Relevance 1.11
Their findings, including a significant upregulation of ephrinB1 and EphB1 in the spinal cord and dorsal root ganglia of adult rat after chronic constriction injury, which was time dependent and correlated with the development of thermal hyperalgesia, support the hypothesis of an involvement of this system in the onset of neuropathic pain.
Positive_regulation (upregulation) of ephrinB1 in dorsal root ganglia associated with thermal hyperalgesia, eae, injury, neuropathic pain and spinal cord
8) Confidence 0.01 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.97 Pain Relevance 0.99

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