INT150286

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.39
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.57
Pain Relevance 2.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Ephb2) molecular_function (Ephb2) cellular_component (Ephb2)
biological_process (Ephb2)
Anatomy Link Frequency
DRG 2
Ephb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 21 99.48 Very High Very High Very High
Eae 22 99.44 Very High Very High Very High
Spinal cord 46 99.16 Very High Very High Very High
Sciatic nerve 2 97.80 Very High Very High Very High
Pain 8 97.32 Very High Very High Very High
dorsal rhizotomy 17 97.08 Very High Very High Very High
Glutamate 3 96.32 Very High Very High Very High
nMDA receptor 28 95.72 Very High Very High Very High
Thermal hyperalgesia 15 83.44 Quite High
Dorsal horn neuron 8 75.00 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 25 99.48 Very High Very High Very High
Injury 17 98.60 Very High Very High Very High
Pain 15 97.32 Very High Very High Very High
Hyperalgesia 27 83.44 Quite High
Congenital Anomalies 1 78.16 Quite High
Targeted Disruption 2 76.68 Quite High
Nervous System Injury 7 75.00 Quite High
Inflammatory Pain 7 68.24 Quite High
Nociception 16 66.96 Quite High
INFLAMMATION 9 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They also showed that in HEK293T cells mutation of the Src-binding site on EphB2 or expression of a dominant negative of Fyn (inhibiting Src family kinases) disabled the phosphorylation of NR2B effect of ephrinB2 and the potentiation of NMDA receptor activity.
Gene_expression (expression) of EphB2 associated with nmda receptor
1) Confidence 0.39 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.22 Pain Relevance 0.31
The present study investigated the correlation between expression of ephrinB and EphB receptor proteins and chronic constriction injury (CCI) of the sciatic nerve and dorsal rhizotomy (DR) in dorsal root ganglion (DRG) and spinal cord (SC); and interaction of CCI and DR on expression of these signals.
Gene_expression (expression) of EphB receptor in DRG associated with ganglion cysts, dorsal root ganglion, dorsal rhizotomy, eae, injury, sciatic nerve and spinal cord
2) Confidence 0.11 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18321739 Disease Relevance 0.86 Pain Relevance 0.91
Western blot and immunobiochemistry analysis and immunofluorescence staining techniques were used to detect the expression and location of the ephrinB-EphB receptor proteins in DRG and SC.
Gene_expression (expression) of EphB receptor in DRG associated with dorsal root ganglion and spinal cord
3) Confidence 0.07 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18321739 Disease Relevance 1.48 Pain Relevance 1.51

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox