INT150287

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 5.54
Pain Relevance 6.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Ephb2) molecular_function (Ephb2) cellular_component (Ephb2)
biological_process (Ephb2)
Anatomy Link Frequency
DRG 3
spinal 1
neurons 1
Ephb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 62 100.00 Very High Very High Very High
dorsal root ganglion 41 100.00 Very High Very High Very High
nociceptor 10 100.00 Very High Very High Very High
Sciatica 8 100.00 Very High Very High Very High
dorsal rhizotomy 33 99.98 Very High Very High Very High
spinal dorsal horn 12 98.76 Very High Very High Very High
Dorsal horn neuron 10 98.56 Very High Very High Very High
Eae 34 97.52 Very High Very High Very High
Peripheral nerve injury 4 97.52 Very High Very High Very High
nMDA receptor 28 97.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 45 100.00 Very High Very High Very High
Nociception 18 99.40 Very High Very High Very High
Nervous System Injury 11 98.08 Very High Very High Very High
Injury 29 97.52 Very High Very High Very High
Neuropathic Pain 22 96.76 Very High Very High Very High
Hyperalgesia 29 91.52 High High
Pain 17 89.08 High High
Inflammatory Pain 7 68.44 Quite High
INFLAMMATION 9 50.00 Quite Low
Congenital Anomalies 1 29.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, EphB2 activation of Src by phosphorylation in cultured hippocampal and cortical neurons could induce NR2A phosphorylation (Grunwald et al., 2001).
Positive_regulation (activation) of EphB2 in neurons
1) Confidence 0.33 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.14 Pain Relevance 0.30
Upregulation and redistribution of ephrinB and EphB receptor in dorsal root ganglion and spinal dorsal horn neurons after peripheral nerve injury and dorsal rhizotomy.
Positive_regulation (Upregulation) of EphB receptor in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, nervous system injury, dorsal rhizotomy, nociceptor, dorsal horn neuron and peripheral nerve injury
2) Confidence 0.10 Published 2008 Journal Eur J Pain Section Title Doc Link 18321739 Disease Relevance 1.05 Pain Relevance 1.46
DR increases ephrinB1 in DRG, not SC and EphB receptor in SC, not DRG.
Neg (not) Positive_regulation (increases) of EphB receptor in DRG associated with dorsal root ganglion, dorsal rhizotomy and spinal cord
3) Confidence 0.07 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18321739 Disease Relevance 1.56 Pain Relevance 1.87
These findings indicate that ephrinB-EphB receptor activation and redistribution in DRG and DH neurons after nerve injury could contribute to neuropathic pain.
Positive_regulation (activation) of EphB receptor in DRG associated with dorsal root ganglion, nervous system injury, spinal dorsal horn and neuropathic pain
4) Confidence 0.06 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18321739 Disease Relevance 1.74 Pain Relevance 1.81
Upregulation and redistribution of ephrinB and EphB receptor in dorsal root ganglion and spinal dorsal horn neurons after peripheral nerve injury and dorsal rhizotomy.
Positive_regulation (Upregulation) of EphB receptor in spinal associated with ganglion cysts, dorsal root ganglion, nervous system injury, dorsal rhizotomy, nociceptor, dorsal horn neuron and peripheral nerve injury
5) Confidence 0.03 Published 2008 Journal Eur J Pain Section Title Doc Link 18321739 Disease Relevance 1.05 Pain Relevance 1.46

General Comments

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