INT150291

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Context Info
Confidence 0.16
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.98
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1) kinase activity (Grk1)
Anatomy Link Frequency
skin 4
Grk1 (Mus musculus)
Igf1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 4 98.88 Very High Very High Very High
Calcitonin gene-related peptide 8 88.72 High High
Root ganglion neuron 2 86.72 High High
Disease Link Frequency Relevance Heat
Alopecia 12 100.00 Very High Very High Very High
Ganglion Cysts 2 86.32 High High
Targeted Disruption 2 80.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These observations strongly suggest that RK might increase dermal IGF-I production through sensory neuron activation, thereby promoting hair growth and increasing skin elasticity.
RK Spec (might) Positive_regulation (increase) of Gene_expression (production) of IGF-I in skin associated with alopecia
1) Confidence 0.16 Published 2008 Journal Growth Horm. IGF Res. Section Abstract Doc Link 18321745 Disease Relevance 0.57 Pain Relevance 0.17
Thus, it is possible that RK activates sensory neurons, thereby increasing skin elasticity and promoting hair growth by increasing dermal IGF-I production.
RK Positive_regulation (increasing) of Gene_expression (production) of IGF-I in skin associated with alopecia
2) Confidence 0.15 Published 2008 Journal Growth Horm. IGF Res. Section Abstract Doc Link 18321745 Disease Relevance 0.41 Pain Relevance 0.39

General Comments

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