INT15033

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Context Info
Confidence 0.78
First Reported 1991
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 18
Total Number 20
Disease Relevance 14.97
Pain Relevance 3.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoe) transport (Apoe) extracellular space (Apoe)
aging (Apoe) extracellular region (Apoe) Golgi apparatus (Apoe)
Anatomy Link Frequency
Purkinje cell 2
coronary artery 1
CSF 1
plaque 1
astrocyte 1
Apoe (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cannabinoid 16 99.88 Very High Very High Very High
cINOD 14 99.52 Very High Very High Very High
Angina 10 97.80 Very High Very High Very High
backache 2 96.76 Very High Very High Very High
Kinase C 6 96.56 Very High Very High Very High
GABAergic 12 96.20 Very High Very High Very High
Inflammation 61 95.60 Very High Very High Very High
aspirin 8 95.28 Very High Very High Very High
Nerve growth factor 2 92.96 High High
long-term potentiation 8 92.08 High High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 144 100.00 Very High Very High Very High
Acute Coronary Syndrome 5 99.76 Very High Very High Very High
Atherosclerotic Plaque 1 99.68 Very High Very High Very High
INFLAMMATION 70 99.20 Very High Very High Very High
Disease 50 99.12 Very High Very High Very High
Atherosclerosis 10 99.12 Very High Very High Very High
Meningoencephalitis 2 98.80 Very High Very High Very High
Coronary Artery Disease 13 98.56 Very High Very High Very High
Motor Neuron Diseases 2 97.96 Very High Very High Very High
Cv General 3 Under Development 7 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Non-steroidal anti-inflammatory drugs mediate increased in vitro glial expression of apolipoprotein E protein.
Gene_expression (expression) of apolipoprotein E associated with inflammation, cinod and disorder of lipid metabolism
1) Confidence 0.78 Published 2003 Journal Eur. J. Neurosci. Section Title Doc Link 14511323 Disease Relevance 0.75 Pain Relevance 0.57
The failure of NSAIDs to significantly alter apoE expression may have been indicative of a nontranscriptional mechanism of apoE protein induction.
Gene_expression (expression) of apoE associated with cinod
2) Confidence 0.78 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14511323 Disease Relevance 0.49 Pain Relevance 0.68
We conclude that astrocyte apolipoprotein E production can be regulated by factors that affect cAMP intracellular concentration or activate protein kinase C.
Gene_expression (production) of apolipoprotein E in astrocyte associated with kinase c and disorder of lipid metabolism
3) Confidence 0.76 Published 2001 Journal Neuroscience Section Abstract Doc Link 11516830 Disease Relevance 0.53 Pain Relevance 0.51
Therefore, understanding the regulated synthesis of apolipoprotein E is important for determining its role in Alzheimer's disease.
Gene_expression (synthesis) of apolipoprotein E associated with disease and disorder of lipid metabolism
4) Confidence 0.76 Published 2001 Journal Neuroscience Section Abstract Doc Link 11516830 Disease Relevance 0.96 Pain Relevance 0.03
Recently, in situ expression of apoE on the atherosclerotic plaque has been studied.
Gene_expression (expression) of apoE in plaque associated with atherosclerotic plaque
5) Confidence 0.74 Published 1999 Journal Yonsei Med. J. Section Abstract Doc Link 10487142 Disease Relevance 1.32 Pain Relevance 0.15
Higher levels of CSF apoE were also present in a subset of patients with meningoencephalitis, motor neuron disease, and low back pain.
Gene_expression (present) of apoE in motor neuron associated with low back pain, meningoencephalitis, motor neuron diseases and backache
6) Confidence 0.56 Published 1997 Journal J. Neurol. Sci. Section Abstract Doc Link 9073026 Disease Relevance 1.24 Pain Relevance 0.13
To evaluate the usefulness of apoE concentration in pathogenesis of AD, we measured the cerebrospinal fluid (CSF) levels of apoE.
Gene_expression (levels) of apoE in CSF associated with disease
7) Confidence 0.56 Published 1997 Journal J. Neurol. Sci. Section Abstract Doc Link 9073026 Disease Relevance 1.17 Pain Relevance 0.08
To validate the microarray results we further examined the protein expression for a subset of selected genes, glial fibrillary protein (GFAP), apolipoprotein E (apo E), cannabinoid type 1 receptor (CB1), Purkinje cell protein 4 (PEP-19), and interleukin 8 receptor (CXCR1), with immunohistochemistry, which confirmed the transcriptome results.
Spec (examined) Gene_expression (expression) of apo E in Purkinje cell associated with cannabinoid and disorder of lipid metabolism
8) Confidence 0.51 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2873964 Disease Relevance 0.96 Pain Relevance 0.25
To validate the microarray results we further examined the protein expression for a subset of selected genes, glial fibrillary protein (GFAP), apolipoprotein E (apo E), cannabinoid type 1 receptor (CB1), Purkinje cell protein 4 (PEP-19), and interleukin 8 receptor (CXCR1), with immunohistochemistry, which confirmed the transcriptome results.
Spec (examined) Gene_expression (expression) of apolipoprotein E in Purkinje cell associated with cannabinoid and disorder of lipid metabolism
9) Confidence 0.51 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2873964 Disease Relevance 0.96 Pain Relevance 0.25
Louis, USA), apolipoprotein E (apo E; 1?
Gene_expression (Louis) of apolipoprotein E associated with disorder of lipid metabolism
10) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.22 Pain Relevance 0.05
Louis, USA), apolipoprotein E (apo E; 1?
Gene_expression (Louis) of apo E associated with disorder of lipid metabolism
11) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.22 Pain Relevance 0.05
The study of this apoE variant should provide additional insight into the structure-function relationship of apoE.
Gene_expression (study) of apoE
12) Confidence 0.30 Published 1991 Journal J. Lipid Res. Section Abstract Doc Link 1713245 Disease Relevance 0.27 Pain Relevance 0.07
The action of lipoprotein lipase on chylomicrons and very low density lipoproteins produces remnant lipoproteins (RLP) rich in triglycerides (TG), cholesterol (C) and apolipoprotein E (apo E).
Gene_expression (produces) of apo E associated with disorder of lipid metabolism
13) Confidence 0.09 Published 1998 Journal Atherosclerosis Section Abstract Doc Link 9712343 Disease Relevance 0.65 Pain Relevance 0.06
The action of lipoprotein lipase on chylomicrons and very low density lipoproteins produces remnant lipoproteins (RLP) rich in triglycerides (TG), cholesterol (C) and apolipoprotein E (apo E).
Gene_expression (produces) of apolipoprotein E associated with disorder of lipid metabolism
14) Confidence 0.09 Published 1998 Journal Atherosclerosis Section Abstract Doc Link 9712343 Disease Relevance 0.65 Pain Relevance 0.06
Serum C, TG, Lp(a), apo E, apo A-I, apo B, HDL-C and RLP-C were measured in 652 patients who underwent diagnostic coronary angiography.
Gene_expression (measured) of apo E associated with disorder of lipid metabolism
15) Confidence 0.08 Published 1998 Journal Atherosclerosis Section Abstract Doc Link 9712343 Disease Relevance 0.85 Pain Relevance 0.08
Bezafibrate produced significant reductions in LDL-C (-17%), total cholesterol (-13%), LDL-C/HDL-C (-24%), triglycerides (-28%), apo B (-15%), and LpA-I (-10%) and significantly increased HDL-C (+12%), apo A-I (+9%), apo A-II (+30%), apo E (+14%), and Lp(a) (+3%).
Gene_expression (produced) of apo E associated with disorder of lipid metabolism
16) Confidence 0.07 Published 1994 Journal Am. J. Med. Section Abstract Doc Link 8017468 Disease Relevance 1.04 Pain Relevance 0.27
Bergmeier et al. [44] observed a high PON1 activity in HDL3 particles isolated by ultracentrifugation, and which contained apo E.
Gene_expression (contained) of apo E
17) Confidence 0.07 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.91 Pain Relevance 0
Bezafibrate produced significant reductions in LDL-C (-17%), total cholesterol (-13%), LDL-C/HDL-C (-24%), triglycerides (-28%), apo B (-15%), and LpA-I (-10%) and significantly increased HDL-C (+12%), apo A-I (+9%), apo A-II (+30%), apo E (+14%), and Lp(a) (+3%).
Gene_expression (reductions) of apo E associated with disorder of lipid metabolism
18) Confidence 0.06 Published 1994 Journal Am. J. Med. Section Abstract Doc Link 8017468 Disease Relevance 1.04 Pain Relevance 0.27
OBJECTIVES: This study was designed to assess the relation between apolipoprotein E (apoE) genotype and serum interleukin (IL)-10 levels in patients with acute coronary syndrome (ACS) and chronic stable angina (CSA).
Gene_expression (levels) of apolipoprotein E associated with acute coronary syndrome, angina and disorder of lipid metabolism
19) Confidence 0.06 Published 2006 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 17174184 Disease Relevance 0.45 Pain Relevance 0.10
Apolipoprotein E genotype and circulating interleukin-10 levels in patients with stable and unstable coronary artery disease.
Gene_expression (levels) of Apolipoprotein E in coronary artery associated with coronary artery disease and disorder of lipid metabolism
20) Confidence 0.05 Published 2006 Journal J. Am. Coll. Cardiol. Section Title Doc Link 17174184 Disease Relevance 0.29 Pain Relevance 0.09

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