INT150338

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0.40
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (F2, F2R) plasma membrane (F2, F2R) peptidase activity (F2)
extracellular space (F2) Golgi apparatus (F2R) signal transducer activity (F2R)
Anatomy Link Frequency
myocardium 4
F2 (Homo sapiens)
F2R (Homo sapiens)
Pain Link Frequency Relevance Heat
Action potential 4 82.72 Quite High
tetrodotoxin 8 70.24 Quite High
agonist 4 59.28 Quite High
antagonist 4 51.84 Quite High
action potential duration 12 25.00 Low Low
ischemia 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Thrombosis 4 99.20 Very High Very High Very High
Suicidal Behaviour 4 25.00 Low Low
Injury 4 5.00 Very Low Very Low Very Low
Coronary Artery Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After the thrombus formation in cardiac cavities or coronaries, the serine protease thrombin is produced and can therefore reach the myocardial tissue by the active process of extravasation and binds to the G protein-coupled protease-activated receptor-1 (PAR1) expressed in human myocardium.
thrombin Binding (binds) of PAR1 in myocardium associated with thrombosis
1) Confidence 0.11 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18326052 Disease Relevance 0.10 Pain Relevance 0.17
After the thrombus formation in cardiac cavities or coronaries, the serine protease thrombin is produced and can therefore reach the myocardial tissue by the active process of extravasation and binds to the G protein-coupled protease-activated receptor-1 (PAR1) expressed in human myocardium.
thrombin Binding (binds) of protein-coupled protease-activated receptor-1 in myocardium associated with thrombosis
2) Confidence 0.10 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18326052 Disease Relevance 0.10 Pain Relevance 0.17
After the thrombus formation in cardiac cavities or coronaries, the serine protease thrombin is produced and can therefore reach the myocardial tissue by the active process of extravasation and binds to the G protein-coupled protease-activated receptor-1 (PAR1) expressed in human myocardium.
serine protease Binding (binds) of PAR1 in myocardium associated with thrombosis
3) Confidence 0.10 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18326052 Disease Relevance 0.10 Pain Relevance 0.17
After the thrombus formation in cardiac cavities or coronaries, the serine protease thrombin is produced and can therefore reach the myocardial tissue by the active process of extravasation and binds to the G protein-coupled protease-activated receptor-1 (PAR1) expressed in human myocardium.
serine protease Binding (binds) of protein-coupled protease-activated receptor-1 in myocardium associated with thrombosis
4) Confidence 0.09 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18326052 Disease Relevance 0.10 Pain Relevance 0.17

General Comments

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