INT150339

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Context Info
Confidence 0.73
First Reported 2004
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 10
Total Number 18
Disease Relevance 3.59
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (F2R) Golgi apparatus (F2R) plasma membrane (F2R)
signal transducer activity (F2R)
Anatomy Link Frequency
myocardium 2
endothelial cells 1
F2R (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 29 97.32 Very High Very High Very High
Inflammation 37 94.24 High High
Pain 813 91.40 High High
c fibre 511 90.92 High High
cytokine 26 88.00 High High
Calcium channel 7 87.36 High High
nociceptor 154 85.60 High High
Action potential 2 83.60 Quite High
Dismenorea 7 83.24 Quite High
tetrodotoxin 4 71.12 Quite High
Disease Link Frequency Relevance Heat
Prostate Cancer 87 99.84 Very High Very High Very High
Metastasis 35 99.68 Very High Very High Very High
Thrombosis 2 96.38 Very High Very High Very High
INFLAMMATION 35 94.24 High High
Pain 757 89.76 High High
Cancer 96 88.04 High High
Hypoxia 2 87.20 High High
Dysmenorrhea 7 83.24 Quite High
Reprotox - General 1 26 81.12 Quite High
Pre-term Labor 7 80.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The collagen embedded hUtSMCs demonstrated expression of the thrombin receptor F2R and the housekeeping gene, ACTB mRNA.
Gene_expression (expression) of F2R
1) Confidence 0.73 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0 Pain Relevance 0
After the thrombus formation in cardiac cavities or coronaries, the serine protease thrombin is produced and can therefore reach the myocardial tissue by the active process of extravasation and binds to the G protein-coupled protease-activated receptor-1 (PAR1) expressed in human myocardium.
Gene_expression (expressed) of PAR1 in myocardium associated with thrombosis
2) Confidence 0.66 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18326052 Disease Relevance 0.10 Pain Relevance 0.17
The collagen embedded hUtSMCs demonstrated expression of the thrombin receptor F2R and the housekeeping gene, ACTB mRNA.
Gene_expression (expression) of thrombin receptor
3) Confidence 0.64 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0 Pain Relevance 0
After the thrombus formation in cardiac cavities or coronaries, the serine protease thrombin is produced and can therefore reach the myocardial tissue by the active process of extravasation and binds to the G protein-coupled protease-activated receptor-1 (PAR1) expressed in human myocardium.
Gene_expression (expressed) of protein-coupled protease-activated receptor-1 in myocardium associated with thrombosis
4) Confidence 0.58 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18326052 Disease Relevance 0.10 Pain Relevance 0.17
We investigated the expression of the thrombin receptor F2R, in the thrombin stimulated gels.
Spec (investigated) Gene_expression (expression) of F2R
5) Confidence 0.57 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0.15 Pain Relevance 0.08
We reported the up-regulation in gene expression of two of its cellular receptors, F2R and F2RL3 at labour [12].
Gene_expression (expression) of F2R
6) Confidence 0.57 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0.22 Pain Relevance 0.15
We have reported an increase in mRNA and protein expression of F2R and F2RL3 at labour [12].
Gene_expression (expression) of F2R
7) Confidence 0.57 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0.41 Pain Relevance 0.25
We have now determined for the first time that thrombin significantly increased both hUtSMC and hTERT-HM collagen contractility and also up-regulated gene expression of its receptor, F2R, in this system.
Gene_expression (expression) of F2R
8) Confidence 0.57 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0.15 Pain Relevance 0.11
We investigated the expression of the thrombin receptor F2R, in the thrombin stimulated gels.
Spec (investigated) Gene_expression (expression) of thrombin receptor
9) Confidence 0.50 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0.15 Pain Relevance 0.08
The exact function of PAR1 expression and thrombin in PCa metastasis has also not been delineated; however, these data suggest that PAR1 enhanced expression on bone-derived PCa cells may be important in targeting these cells to the bone [11].
Gene_expression (expression) of thrombin associated with prostate cancer and metastasis
10) Confidence 0.25 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC320496 Disease Relevance 1.18 Pain Relevance 0.05
A number of markers expressed by the MDA-MB-231 cells, including thrombin receptor, TIE-2, CD31, VEGF, and bc-48, have been shown to be associated with endothelial cells [30-34].
Gene_expression (expressed) of thrombin receptor in endothelial cells
11) Confidence 0.09 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0.72 Pain Relevance 0
In the representation which expresses the reaction time tR according to the inverse of the slope ?
Gene_expression (expresses) of tR
12) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859063 Disease Relevance 0 Pain Relevance 0.13
C; (9) constructing the graph tR?
Gene_expression (constructing) of tR
13) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859063 Disease Relevance 0 Pain Relevance 0.09
T0)2 in function of the reaction time tR (figure 5C) or the reaction time tR in function of the inverse of the slope ?
Gene_expression (figure) of tR
14) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859063 Disease Relevance 0.08 Pain Relevance 0.26
The psychophysical latency was given by the constant term of the equation which expressed the reaction time tR according to the inverse of the slope 1/?
Gene_expression (expressed) of tR
15) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859063 Disease Relevance 0.09 Pain Relevance 0.16
T0)2 in function of the reaction time tR (figure 5C) or the reaction time tR in function of the inverse of the slope ?
Gene_expression (function) of tR
16) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859063 Disease Relevance 0.08 Pain Relevance 0.26
T0)2 in function of the reaction time tR (figure 5C) or the reaction time tR in function of the inverse of the slope ?
Gene_expression (function) of tR
17) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859063 Disease Relevance 0.08 Pain Relevance 0.26
T0)2 in function of the reaction time tR (figure 5C) or the reaction time tR in function of the inverse of the slope ?
Gene_expression (figure) of tR
18) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859063 Disease Relevance 0.08 Pain Relevance 0.25

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