INT150348

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.38
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)
Oprd1 (Rattus norvegicus)
Pat (Mus musculus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 4 100.00 Very High Very High Very High
agonist 3 99.72 Very High Very High Very High
Morphine 11 98.40 Very High Very High Very High
tolerance 9 97.92 Very High Very High Very High
Antinociceptive 3 97.52 Very High Very High Very High
antagonist 1 94.32 High High
nMDA receptor antagonist 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 6 100.00 Very High Very High Very High
Nociception 3 58.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we compared the effect of PAT, trans-(+/-)-3,4-dichloro-N-methyl-N-(2-(1-pyrrolidin)cyclohexyl)-benzeneacetamide methane sulfonate hydrate (U50488H), a selective kappa opioid receptor (KOR) agonist, and (-)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine-maleate (MK-801), a N-methyl-D-aspartate (NMDA) receptor antagonist, on the antinociceptive tolerance to morphine in the same experimental condition.
opioid receptor Regulation (effect) of PAT associated with heart rate under development, antagonist, tolerance, agonist, kappa opioid receptor, antinociceptive and morphine
1) Confidence 0.01 Published 2008 Journal J Ethnopharmacol Section Abstract Doc Link 18328652 Disease Relevance 0.38 Pain Relevance 0.81

General Comments

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