INT150366

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.17
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Nfkb1, Pomc) signal transduction (Nfkb1, Pomc) mitochondrion (Nfkb1)
DNA binding (Nfkb1) protein complex (Nfkb1) cell-cell signaling (Pomc)
Anatomy Link Frequency
arcuate nucleus 2
Nfkb1 (Mus musculus)
Pomc (Mus musculus)
Pain Link Frequency Relevance Heat
IPN 2 99.08 Very High Very High Very High
Glutamate 1 48.44 Quite Low
substance P 1 44.24 Quite Low
intrathecal 1 43.48 Quite Low
Pain 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Inflammatory Pain 2 99.08 Very High Very High Very High
Nociception 1 34.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, POMC mRNA expression in the arcuate nucleus of the hypothalamus was increased by inflammatory pain stimuli, in which pERK1/2, pCaMK-IIalpha and NFkappaB may play an important role in the expression of the hypothalamic POMC gene and beta-endorphin expression.
NFkappaB Regulation (role) of Gene_expression (expression) of POMC gene in arcuate nucleus associated with ipn
1) Confidence 0.03 Published 2008 Journal Neuroscience Section Abstract Doc Link 18329177 Disease Relevance 0.17 Pain Relevance 0.17

General Comments

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