INT150391

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 10
Disease Relevance 3.00
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MEFV, PYCARD) intracellular (MEFV, PYCARD) cytoplasm (MEFV, PYCARD)
signal transduction (PYCARD) cytoskeleton (MEFV) nucleus (MEFV)
Anatomy Link Frequency
filaments 1
MEFV (Homo sapiens)
PYCARD (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 66 98.08 Very High Very High Very High
Pain 17 82.24 Quite High
Arthritis 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 9 100.00 Very High Very High Very High
INFLAMMATION 66 98.08 Very High Very High Very High
Disease 70 95.88 Very High Very High Very High
Fever 89 91.00 High High
Stress 3 87.20 High High
Syndrome 66 84.24 Quite High
Pain 17 82.24 Quite High
Osteomyelitis 28 5.00 Very Low Very Low Very Low
Arthritis 14 5.00 Very Low Very Low Very Low
Acne 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, using a novel protein/protein interaction assay, we demonstrate that pyrin can recruit Siva to ASC specks, establishing a potential platform for intersection of ASC and Siva function.
pyrin Binding (recruit) of ASC
1) Confidence 0.14 Published 2008 Journal J. Cell. Physiol. Section Abstract Doc Link 18330885 Disease Relevance 0.75 Pain Relevance 0.09
Furthermore, using a novel protein/protein interaction assay, we demonstrate that pyrin can recruit Siva to ASC specks, establishing a potential platform for intersection of ASC and Siva function.
pyrin Binding (recruit) of ASC
2) Confidence 0.14 Published 2008 Journal J. Cell. Physiol. Section Abstract Doc Link 18330885 Disease Relevance 0.75 Pain Relevance 0.09
Previous reports have established that pyrin interacts with the apoptotic protein ASC, the cytoskeletal adaptor protein PSTPIP1, the inflammatory caspase, Caspase-1 and certain forms of the cytosolic anchoring protein 14-3-3.
pyrin Binding (interacts) of ASC associated with inflammation and apoptosis
3) Confidence 0.12 Published 2008 Journal J. Cell. Physiol. Section Abstract Doc Link 18330885 Disease Relevance 0.77 Pain Relevance 0.13
Rather, pyrin interacts readily with ASC both in the presence or absence of PSTPIP1.
pyrin Binding (interacts) of ASC
4) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.18 Pain Relevance 0.05
A second difference between our findings and those of earlier studies is that we find that pyrin is not sequestered away from ASC by its interaction by PSTPIP1, and does not require PSTPIP1 to interact with ASC.
pyrin Binding (interact) of ASC
5) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.19 Pain Relevance 0.05
Third, and most importantly, in the presence of ASC, pyrin recruits PSTPIP1 to the ASC speck compartment, a compartment that PSTPIP1 never visits in the absence of pyrin.
pyrin Binding (recruits) of ASC
6) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.16 Pain Relevance 0.04
Together, these data establish that pyrin interacts more readily with ASC than with PSTPIP1 and that recruitment of PSTPIP1 to the speck compartment is pyrin-dependent.
pyrin Binding (interacts) of ASC
7) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.08 Pain Relevance 0
Pyrin can interact with both PSTPIP1 [5] and ASC [32].
Pyrin Binding (interact) of ASC
8) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.07 Pain Relevance 0
In this model, then, PSTPIP1 is required for pyrin's functional interaction with the ASC inflammasome.
pyrin Binding (interaction) of ASC
9) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.06 Pain Relevance 0.03
In these latter cases, pyrin is observed either in association with both specks and PSTPIP1 filaments (Figure 9K–M) or exclusively in ASC specks (Figure 7N–P).
pyrin Binding (association) of ASC in filaments
10) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0

General Comments

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