INT150393

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Context Info
Confidence 0.16
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.48
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP1, MEFV) intracellular (CASP1, MEFV) cytoplasm (CASP1, MEFV)
peptidase activity (CASP1) signal transduction (CASP1) cytoskeleton (MEFV)
CASP1 (Homo sapiens)
MEFV (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 5 100.00 Very High Very High Very High
anakinra 4 89.68 High High
antagonist 3 85.44 High High
Pain 2 82.24 Quite High
Arthritis 3 77.36 Quite High
spinal inflammation 1 76.56 Quite High
psoriasis 1 75.60 Quite High
Crohn's disease 3 71.36 Quite High
corticosteroid 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 4 100.00 Very High Very High Very High
Apoptosis 3 100.00 Very High Very High Very High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 6 97.36 Very High Very High Very High
Fever 12 96.96 Very High Very High Very High
Disease 19 96.36 Very High Very High Very High
Syndrome 20 93.40 High High
Pain 1 82.24 Quite High
Immune System Diseases 3 81.24 Quite High
Seronegative Spondarthritis 1 77.36 Quite High
Low Back Pain 1 76.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous reports have established that pyrin interacts with the apoptotic protein ASC, the cytoskeletal adaptor protein PSTPIP1, the inflammatory caspase, Caspase-1 and certain forms of the cytosolic anchoring protein 14-3-3.
Caspase-1 Binding (interacts) of pyrin associated with inflammation and apoptosis
1) Confidence 0.16 Published 2008 Journal J. Cell. Physiol. Section Abstract Doc Link 18330885 Disease Relevance 0.78 Pain Relevance 0.13
In vitro and murine studies have shown that the B30.2 domain of pyrin interacts directly with caspase-1 to modulate IL-1?
caspase-1 Binding (interacts) of pyrin
2) Confidence 0.09 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948378 Disease Relevance 1.70 Pain Relevance 0.31

General Comments

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