INT150395

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Context Info
Confidence 0.44
First Reported 2003
Last Reported 2010
Negated 2
Speculated 4
Reported most in Body
Documents 55
Total Number 59
Disease Relevance 31.18
Pain Relevance 3.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MEFV) cytoskeleton (MEFV) nucleus (MEFV)
intracellular (MEFV) cytoplasm (MEFV)
Anatomy Link Frequency
filaments 8
SH3 6
peritoneum 1
tail 1
skin 1
MEFV (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 10 100.00 Very High Very High Very High
cytokine 13 99.98 Very High Very High Very High
Inflammation 1075 99.56 Very High Very High Very High
Fibrositis 97 97.76 Very High Very High Very High
Inflammatory response 20 97.36 Very High Very High Very High
abdominal pain 32 96.48 Very High Very High Very High
Arthritis 83 90.12 High High
Crohn's disease 3 85.20 High High
chemokine 12 84.56 Quite High
corticosteroid 5 81.04 Quite High
Disease Link Frequency Relevance Heat
Fever 1518 100.00 Very High Very High Very High
Syndrome 381 100.00 Very High Very High Very High
Celiac Disease 65 100.00 Very High Very High Very High
Rheumatoid Arthritis 10 100.00 Very High Very High Very High
Congenital Anomalies 3 100.00 Very High Very High Very High
Rift Valley Fever 1 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 81 99.92 Very High Very High Very High
Sacroiliitis 1 99.76 Very High Very High Very High
Milium 10 99.60 Very High Very High Very High
INFLAMMATION 1113 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show here that pyrin can not only bind to these filamentous, PSTPIP-coated membrane tubules, but can also alter their distribution.
pyrin Binding (bind) of in tubules
1) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.23 Pain Relevance 0.04
In addition, we explore the connection between PSTPIP1 filaments and the cellular cytoskeleton and demonstrate that pyrin binding affects PSTPIP1 filament distribution.
pyrin Binding (binding) of in filaments
2) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.16 Pain Relevance 0.04
We also examine the pyrin/PSTPIP1 interaction and show that contrary to earlier predictions [5], the PSTPIP1 SH3 domain is not required for its interaction with pyrin.
pyrin Spec (examine) Binding (interaction) of in SH3
3) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.21 Pain Relevance 0
The model also suggests that the coherent convex binding surface would likely interact with both pyrin and the PEST phosphatases, since these PSTPIP1 mutations have been shown to reduce binding affinity for PEST phosphatases and increase affinity for pyrin (Shoham, 2005).


pyrin Binding (interact) of
4) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.06 Pain Relevance 0
In contrast, the W232A mutation in PSTPIP1 abolished pyrin binding; consequently, PSTPIP1 filaments were primarily straight, not extensively branched (Figure 4I–K), confirming that the reticularization of PSTPIP1 filaments is a direct consequence of pyrin binding.
pyrin Binding (binding) of in filaments
5) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0
The results of these analyses suggest a revised model of pyrin/PSTPIP interaction in the context of inflammatory disease.


pyrin Binding (interaction) of associated with inflammation and disease
6) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.20 Pain Relevance 0.05
In contrast, the W232A mutation in PSTPIP1 abolished pyrin binding; consequently, PSTPIP1 filaments were primarily straight, not extensively branched (Figure 4I–K), confirming that the reticularization of PSTPIP1 filaments is a direct consequence of pyrin binding.
pyrin Binding (binding) of in filaments
7) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0
Since disease-associated mutations in PSTPIP1 enhance pyrin binding, PAPA syndrome and FMF are thought to share a common pathoetiology.
pyrin Binding (binding) of associated with syndrome, fever and disease
8) Confidence 0.44 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2702820 Disease Relevance 0.94 Pain Relevance 0.05
Patients with FMF are considered to have an increased risk of sacroiliitis, while the association of such abnormalities with FMF has not been accepted uniformly.
FMF Binding (association) of associated with sacroiliitis, congenital anomalies and fever
9) Confidence 0.42 Published 2009 Journal Singapore Med J Section Abstract Doc Link 19352557 Disease Relevance 1.12 Pain Relevance 0.10
To date, more than forty missense mutations are noted in association with FMF.
FMF Binding (association) of associated with fever
10) Confidence 0.42 Published 2003 Journal BMC Nephrol Section Body Doc Link PMC194618 Disease Relevance 1.89 Pain Relevance 0.09
The novel association between FMF and fibrillary glomerulopathy in this patient raises two contingent questions.
FMF Binding (association) of associated with fever
11) Confidence 0.42 Published 2003 Journal BMC Nephrol Section Body Doc Link PMC194618 Disease Relevance 1.67 Pain Relevance 0.30
Taken together, these data confirm that PSTPIP1 shares the lipid membrane-binding properties of several other F-BAR domain-containing proteins, a property that is not affected by pyrin binding.


pyrin Binding (binding) of
12) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.05 Pain Relevance 0
The pyrin homotrimer, they propose, is autoinhibited by the association of its pyrin domain (PyD) with its own B-box.
pyrin Binding (association) of
13) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.08 Pain Relevance 0.04
, the chief cytokine associated with functional analysis of the pyrin protein (protein product of the MEFV gene), were high in FMS patients with the rare MEFV alleles, but not in unrelated controls or FMS patients with wild type MEFV.
pyrin Binding (associated) of associated with fibrositis and cytokine
14) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 0.65 Pain Relevance 0.53
Finally, we examine the binding relationships between PSTPIP1, pyrin, and the pyrin-binding protein ASC.
pyrin Spec (examine) Binding (binding) of
15) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.18 Pain Relevance 0.05
We therefore examined the effect of the W232A mutation and the requirement for the SH3 domain on pyrin's recruitment to and reticularization of PSTPIP1 filaments.
pyrin Spec (examined) Binding (recruitment) of in SH3
16) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0
To explore the effect of PAPA mutations on the PSTPIP1:pyrin interaction, we next tested whether the filaments formed by mutant forms of PSTPIP1 could be reorganized by pyrin.
pyrin Binding (interaction) of in filaments
17) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.15 Pain Relevance 0
Finally, we directly test the binding relationships between PSTPIP1, pyrin, and the pyrin-binding protein ASC.
pyrin Binding (binding) of
18) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.38 Pain Relevance 0.04
The binding of PSTPIP1 and pyrin was previously studied by immunoprecipitation and the SH3 domain of PSTPIP1 was found to be necessary but not sufficient for this interaction [5].
pyrin Binding (binding) of in SH3
19) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0
Thus, the SH3 domain is apparently dispensable for the interaction between pyrin and PSTPIP1.
pyrin Binding (interaction) of in SH3
20) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0

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