INT15040

Context Info Confidence 0.65 First Reported 1991 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 8 Total Number 9 Disease Relevance 3.95 Pain Relevance 1.02

nucleoplasm (NKX2-1) anatomical structure formation involved in morphogenesis (NKX2-1) nucleus (NKX2-1) DNA binding (NKX2-1)

Anatomy Link Frequency thyroid 4 lung epithelium 1 respiratory 1 NKX2-1 (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 3 99.70 substance P 5 99.36 qutenza 2 93.88 anesthesia 4 93.00 gABA 68 90.36 antagonist 5 89.12 Potency 1 72.16 corticosteroid 5 39.72 fibrosis 26 34.84 imagery 14 29.28

Disease Link Frequency Relevance Heat Disease 91 100.00 Interstitial Lung Diseases 143 99.92 Thyroid Neoplasm 5 99.90 Carcinoma 10 97.24 Adenocarcinoma 6 96.68 Thyroid Nodule 1 94.48 Bone Cancer 7 93.64 Hepatocellular Cancer 22 92.08 Lung Cancer 12 90.16 Toxicity 1 89.12

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

ICSI was performed using Eppendorf Micromanipulators (TransferMan NK2) with a piezo-electric actuator (Piezo Impact Micro-Manipulator, PMM-150FU System; PrimeTech, Ibaraki, Japan).

Gene_expression (using) of NK2

1) Confidence 0.65 Published 2005 Journal BMC Genomics Section Body Doc Link PMC1325271 Disease Relevance 0 Pain Relevance 0

Last step was to determine if there was expression of cell-specific structures or receptors that are unique identifiers of cell types, for example neuroendocrine granules, peptide hormones, thyroglobulin, Prostate Specific Antigen (PSA), Gross Cystic Disease Fluid Protein (GCDFP) or Thyroid Transcription Factor-1 (TTF-1).

Spec (determine) Gene_expression (expression) of TTF-1 in Thyroid associated with disease

2) Confidence 0.58 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1310632 Disease Relevance 0.86 Pain Relevance 0

Thyroid transcription factor 1 (known as TTF-1, Nkx2.1, or T/EBP) is a homeodomain containing transcription factor expressed in thyroid and lung epithelium and in restricted regions of the fetal brain (Kimura et al., 1996; Lazzaro et al., 1991).

Gene_expression (expressed) of TTF-1 in lung epithelium

3) Confidence 0.58 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525920 Disease Relevance 0 Pain Relevance 0.21

Later, the immunohistochemical examination revealed that cytokeratin 7 (CK7) and thyroid transcription factor 1 (TTF-1) were distinctly detected but cytokeratin 20 (CK20) never expressed.

Gene_expression (detected) of thyroid transcription factor 1 in thyroid

4) Confidence 0.50 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1821329 Disease Relevance 1.20 Pain Relevance 0.09

Immunohistochemical staining showed that the thyroid carcinoma was negative for thyroid transcription factor-1 (TTF-1), CK 7, CK 20, and thyroglobulin.

Neg (negative) Gene_expression (negative) of thyroid transcription factor-1 in thyroid associated with thyroid neoplasm

5) Confidence 0.42 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2246133 Disease Relevance 1.41 Pain Relevance 0

Another contributor of ILD is TTF-1 (NK2 homeobox 1) dysfunction.

Gene_expression (dysfunction) of TTF-1 associated with interstitial lung diseases

6) Confidence 0.22 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2939531 Disease Relevance 0.48 Pain Relevance 0

Thyroid transcription factor 1 (known as TTF-1, Nkx2.1, or T/EBP) is a homeodomain containing transcription factor expressed in thyroid and lung epithelium and in restricted regions of the fetal brain (Kimura et al., 1996; Lazzaro et al., 1991).

Gene_expression (expressed) of TTF-1 in thyroid

7) Confidence 0.20 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525920 Disease Relevance 0 Pain Relevance 0.21

Experiments with natural and synthetic tachykinin agonists indicated the presence of both NK-1 and NK-2 receptors at this level.

Gene_expression (presence) of NK-2 associated with agonist

8) Confidence 0.04 Published 1991 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 1713430 Disease Relevance 0 Pain Relevance 0.31

Stimulation of sensory nerves causes release of tachykinins, including substance P (SP) and neurokinin A (NKA), which produce a variety of respiratory effects via NK-1 and NK-2 receptors, respectively.

Gene_expression (produce) of NK-2 in respiratory associated with substance p

9) Confidence 0.03 Published 1997 Journal J Auton Pharmacol Section Abstract Doc Link 9234081 Disease Relevance 0 Pain Relevance 0.20

General Comments

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