INT15042

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 1991
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 37
Total Number 37
Disease Relevance 3.77
Pain Relevance 14.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Adora2a) enzyme binding (Adora2a) signal transducer activity (Adora2a)
Anatomy Link Frequency
striatum 6
NG108-15 3
neurons 3
ileum 2
plasma 2
Adora2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 926 100.00 Very High Very High Very High
antagonist 314 100.00 Very High Very High Very High
medulla 5 100.00 Very High Very High Very High
Enkephalin 28 99.84 Very High Very High Very High
imagery 1 99.64 Very High Very High Very High
agonist 1427 99.62 Very High Very High Very High
Locus ceruleus 3 99.54 Very High Very High Very High
Dopamine 31 99.52 Very High Very High Very High
substance P 21 98.96 Very High Very High Very High
Substantia nigra 6 97.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Glioma 13 99.72 Very High Very High Very High
Neuroblastoma 53 99.54 Very High Very High Very High
Pheochromocytoma 13 99.40 Very High Very High Very High
Necrosis 13 97.68 Very High Very High Very High
Cancer 207 97.32 Very High Very High Very High
Disease 89 97.32 Very High Very High Very High
Anxiety Disorder 49 97.12 Very High Very High Very High
Hyperalgesia 13 95.32 Very High Very High Very High
Parkinson's Disease 5 95.32 Very High Very High Very High
Nociception 3 92.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adenosine A2A receptors, highly expressed on striatal medium spiny neurons, signal via kinases whose aberrant activation has been linked to the appearance of parkinsonian signs after dopaminergic denervation and to the motor response complications produced by dopaminomimetic therapy.
Gene_expression (expressed) of A2A in neurons associated with parkinson's disease and adenocard
1) Confidence 0.77 Published 2003 Journal Neurology Section Abstract Doc Link 14663022 Disease Relevance 0.45 Pain Relevance 0.29
During postnatal development, alpha-2 adrenergic receptors (A2AR) change in both density and distribution.
Gene_expression (change) of A2AR
2) Confidence 0.66 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027851 Disease Relevance 0 Pain Relevance 0.07
The absence of a change in A2A receptor gene expression after 6-OH-dopamine treatment speaks against a dependency on dopaminergic innervation.
Gene_expression (expression) of A2A receptor gene associated with dopamine
3) Confidence 0.65 Published 2000 Journal J Neural Transm Section Abstract Doc Link 11041267 Disease Relevance 0 Pain Relevance 0.66
Adenosine A2A receptor gene expression in the normal striatum and after 6-OH-dopamine lesion.
Gene_expression (expression) of A2A receptor gene in striatum associated with dopamine and adenocard
4) Confidence 0.65 Published 2000 Journal J Neural Transm Section Title Doc Link 11041267 Disease Relevance 0 Pain Relevance 0.53
The results showed high expression of A2A adenosine receptor genes only in the medium-sized cells of the striatum in all examined species.
Gene_expression (expression) of A2A in striatum associated with adenocard
5) Confidence 0.65 Published 2000 Journal J Neural Transm Section Abstract Doc Link 11041267 Disease Relevance 0 Pain Relevance 0.63
In the rat striatum, expression of A2A receptors was not significantly altered after lesion of the dopaminergic pathways with 6-OH-dopamine even though enkephalin gene expression was up-regulated.
Gene_expression (expression) of A2A in striatum associated with dopamine and enkephalin
6) Confidence 0.65 Published 2000 Journal J Neural Transm Section Abstract Doc Link 11041267 Disease Relevance 0 Pain Relevance 0.65
In order to establish more accurately whether adenosine transmission is a generalized phenomenon in mammalian striatum we compared the A2A R expression in the mouse, rat, cat and human striatum.
Gene_expression (expression) of A2A in striatum associated with adenocard
7) Confidence 0.65 Published 2000 Journal J Neural Transm Section Abstract Doc Link 11041267 Disease Relevance 0 Pain Relevance 0.46
Secondly we compared the modulation of enkephalin gene expression and A2A receptor gene expression in rat striatal neurons after 6-OH-dopamine lesion of the substantia nigra.
Gene_expression (expression) of A2A receptor gene in substantia nigra associated with dopamine, substantia nigra and enkephalin
8) Confidence 0.65 Published 2000 Journal J Neural Transm Section Abstract Doc Link 11041267 Disease Relevance 0 Pain Relevance 0.52
Generation of recombinant adeno-associated virus (rAAV)
Gene_expression (Generation) of adeno
9) Confidence 0.65 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2219998 Disease Relevance 0.08 Pain Relevance 0.03
Striatal restricted adenosine A2 receptor (RDC8) is expressed by enkephalin but not by substance P neurons: an in situ hybridization histochemistry study.
Neg (not) Gene_expression (expressed) of adenosine A2 receptor in neurons associated with adenocard, enkephalin and substance p
10) Confidence 0.60 Published 1991 Journal J. Neurochem. Section Title Doc Link 1713612 Disease Relevance 0 Pain Relevance 0.75
Our results demonstrate that the adenosine A2 receptor is expressed exclusively by the enkephalinergic striatal subpopulation but not by the substance P-containing or cholinergic neurons.
Neg (not) Gene_expression (expressed) of adenosine A2 receptor in cholinergic neurons associated with adenocard and substance p
11) Confidence 0.60 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1713612 Disease Relevance 0 Pain Relevance 0.44
This binding increases more slowly than receptor number, suggesting that the appearance of G proteins, rather than the A2AR, determines the developmental appearance of functional A2AR-G protein interactions in forebrain.
Gene_expression (appearance) of A2AR in forebrain
12) Confidence 0.59 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027851 Disease Relevance 0 Pain Relevance 0.29
Production of recombinant adenovirus (rAdv) and adeno-associated virus (rAAV)
Gene_expression (Production) of adeno
13) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2938346 Disease Relevance 0.26 Pain Relevance 0
treatment of human monocytoid THP-1 cells expressing the A2AR prevented desensitization of this receptor, occurring under control conditions upon pretreatment with CGS21680 or NECA [69].
Gene_expression (expressing) of A2AR in THP-1
14) Confidence 0.50 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.20 Pain Relevance 0.20
Rat pheochromocytoma PC12 cells also endogenously express both A2AR and A2BR.
Gene_expression (express) of A2AR associated with pheochromocytoma
15) Confidence 0.50 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.10 Pain Relevance 0.19
NG108-15 neuroblastoma x glioma hybrid cells express both A2AR and A2BR [60, 61].
Gene_expression (express) of A2AR in NG108-15 associated with neuroblastoma and glioma
16) Confidence 0.50 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.20 Pain Relevance 0.34
In the CNS, the A2AR is highly expressed in the striatum and olfactory tubercle [1].
Gene_expression (expressed) of A2AR in striatum
17) Confidence 0.50 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.90 Pain Relevance 0.57
In NG108-15 cells, expressing both A2AR and A2BR, the rate of desensitization for both receptor subtypes appeared similar, with a half-life of 15–20 min.
Gene_expression (expressing) of A2AR in NG108-15
18) Confidence 0.50 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.08 Pain Relevance 0.24
Wild-type GRK2 was stably expressed in NG108-15 cells, which endogenously express A2AR and A2BR.
Gene_expression (express) of A2AR in NG108-15
19) Confidence 0.50 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0 Pain Relevance 0.21
Ramkumar et al. pretreated DDT1 MF-2 cells, a smooth muscle cell line expressing both A1 and A2A receptors, with R-phenylisopropyl adenosine (R-PIA) for up to 24 h, after which the adenylyl cyclase activity was reduced by approximately 50%.
Gene_expression (expressing) of A2A in smooth muscle cell associated with adenocard
20) Confidence 0.50 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0 Pain Relevance 0.31

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox