INT150456

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.64
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sort1) endosome (Sort1) transport (Sort1)
Golgi apparatus (Sort1) endoplasmic reticulum (Sort1) intracellular (Sort1)
Anatomy Link Frequency
spinal 1
Sort1 (Rattus norvegicus)
Nts (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 138 100.00 Very High Very High Very High
Antinociceptive 30 99.76 Very High Very High Very High
GABAergic 10 96.48 Very High Very High Very High
Eae 15 96.12 Very High Very High Very High
intrathecal 27 91.56 High High
Lasting pain 33 90.64 High High
analgesia 27 89.80 High High
medulla 9 84.48 Quite High
Hippocampus 6 78.32 Quite High
Calcium channel 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Pain 12 96.12 Very High Very High Very High
Pain 183 90.64 High High
Nociception 135 73.20 Quite High
INFLAMMATION 45 54.32 Quite High
Low Back Pain 6 52.88 Quite High
Toxicity 3 31.60 Quite Low
Ganglion Cysts 15 5.00 Very Low Very Low Very Low
Injury 12 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 9 5.00 Very Low Very Low Very Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neurotensin (NT) is a tridecapeptide that interacts with three NT receptors; NTS1, NTS2, and NTS3.
NTS1 Binding (interacts) of Neurotensin
1) Confidence 0.45 Published 2008 Journal J. Neurophysiol. Section Abstract Doc Link 18337367 Disease Relevance 0 Pain Relevance 0.33
Neurotensin (NT) is a tridecapeptide that interacts with three NT receptors; NTS1, NTS2, and NTS3.
NTS3 Binding (interacts) of Neurotensin
2) Confidence 0.33 Published 2008 Journal J. Neurophysiol. Section Abstract Doc Link 18337367 Disease Relevance 0 Pain Relevance 0.33
Our results also suggest that a dichotomy exists between the spinal antinociceptive actions of NTS2-selective agonists and NTS1/NTS2 mixed compounds.
NTS1 Binding (compounds) of NTS2 in spinal associated with agonist and antinociceptive
3) Confidence 0.15 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714839 Disease Relevance 0.45 Pain Relevance 0.87
In addition, the NT(8–13) analog NT69L, which contains a L-neo-tryptophan amino acid, and exhibits high affinity for both rat (IC50 = 2.2 ± 0.5 nM) and human NTS1 [49] also appeared as a ligand with a good affinity for the rat NTS2 (IC50 = 3.7 ± 0.4 nM).
NTS1 Spec (appeared) Binding (ligand) of NTS2
4) Confidence 0.13 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714839 Disease Relevance 0.19 Pain Relevance 0.19
Thus, the metabolically stable NT(8–13) analog JMV-431, protected at its N-terminus by a Boc group and by a reduced pseudopeptide bond Y(CH2NH) in position 11–12 binds with 250 times greater affinity to rat NTS2 (IC50 = 19 ± 3 nM) than to rat NTS1 (IC50 = 4735 ± 100 nM).
NTS1 Binding (affinity) of NTS2
5) Confidence 0.11 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714839 Disease Relevance 0 Pain Relevance 0.07

General Comments

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