INT150457

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 1.36
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sort1) endosome (Sort1) transport (Sort1)
Golgi apparatus (Sort1) endoplasmic reticulum (Sort1) intracellular (Sort1)
Sort1 (Rattus norvegicus)
Prss12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 138 100.00 Very High Very High Very High
antinociception 24 98.34 Very High Very High Very High
Pain 141 98.28 Very High Very High Very High
Inflammation 42 96.96 Very High Very High Very High
GABAergic 10 96.48 Very High Very High Very High
Eae 15 95.24 Very High Very High Very High
tail-flick 9 89.56 High High
Antinociceptive 30 88.20 High High
Lasting pain 33 85.64 High High
analgesia 27 84.44 Quite High
Disease Link Frequency Relevance Heat
Pain 183 98.28 Very High Very High Very High
INFLAMMATION 45 96.96 Very High Very High Very High
Inflammatory Pain 12 95.24 Very High Very High Very High
Nociception 135 89.92 High High
Ganglion Cysts 15 71.52 Quite High
Urological Neuroanatomy 9 70.16 Quite High
Targeted Disruption 3 58.44 Quite High
Injury 12 5.00 Very Low Very Low Very Low
Low Back Pain 6 5.00 Very Low Very Low Very Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neurotensin (NT) is a tridecapeptide that interacts with three NT receptors; NTS1, NTS2, and NTS3.
NTS1 Binding (interacts) of NT
1) Confidence 0.21 Published 2008 Journal J. Neurophysiol. Section Abstract Doc Link 18337367 Disease Relevance 0 Pain Relevance 0.33
Neurotensin (NT) is a tridecapeptide that interacts with three NT receptors; NTS1, NTS2, and NTS3.
NTS3 Binding (interacts) of NT
2) Confidence 0.20 Published 2008 Journal J. Neurophysiol. Section Abstract Doc Link 18337367 Disease Relevance 0 Pain Relevance 0.33
The involvement of additional receptors is indeed suggested by the finding that the reversal by SR48692 of the antinociception produced by PD149163 was more complete than of that induced by NT69L, a peptidase resistant NT analog which binds to both NTS1 and NTS2 receptors with high affinity, but in a non-selective manner [37].
NTS1 Binding (binds) of resistant NT associated with antinociception
3) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714839 Disease Relevance 0.85 Pain Relevance 1.08
We first demonstrated that spinally administered NT and NT69L agonists, which bind to both NTS1 and NTS2 receptors, significantly reduced pain-evoked responses during the inflammatory phase of the formalin test.
NTS1 Binding (bind) of NT associated with pain, inflammation and agonist
4) Confidence 0.04 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2714839 Disease Relevance 0.52 Pain Relevance 0.78
Thus, the metabolically stable NT(8–13) analog JMV-431, protected at its N-terminus by a Boc group and by a reduced pseudopeptide bond Y(CH2NH) in position 11–12 binds with 250 times greater affinity to rat NTS2 (IC50 = 19 ± 3 nM) than to rat NTS1 (IC50 = 4735 ± 100 nM).
NTS1 Binding (affinity) of NT
5) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714839 Disease Relevance 0 Pain Relevance 0.13

General Comments

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