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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.24
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ntrk2) endosome (Ntrk2) aging (Ntrk2)
plasma membrane (Ntrk2)
Anatomy Link Frequency
neuronal 2
dorsal root ganglia 2
Ntrk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 1 95.68 Very High Very High Very High
Nerve growth factor 6 95.36 Very High Very High Very High
Neuropathic pain 2 79.60 Quite High
tetrodotoxin 2 77.12 Quite High
Pain 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 3 86.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They induced differentiation of chick dorsal root ganglia and stimulated tyrosine phosphorylation of TrkA, but not TrkB, receptor.
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of TrkB in dorsal root ganglia
1) Confidence 0.42 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18337399 Disease Relevance 0.24 Pain Relevance 0.44
Here we found that, in cultured rat cortical neurons, bidirectional changes of neuronal activity led to corresponding alterations in the expression of brain-derived neurotrophic factor (BDNF) and phosphorylation of its receptor tropomyosin-related kinase B (TrkB), as well as in the level of synaptic proteins.
Positive_regulation (alterations) of Phosphorylation (phosphorylation) of TrkB in neuronal
2) Confidence 0.40 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18474605 Disease Relevance 0 Pain Relevance 0.08

General Comments

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