INT150464

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 4.39
Pain Relevance 4.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2ry12) plasma membrane (P2ry12) signal transducer activity (P2ry12)
Anatomy Link Frequency
microglial cells 4
P2ry12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
neuralgia 2 100.00 Very High Very High Very High
Inflammation 155 99.36 Very High Very High Very High
Snapping jaw 126 98.84 Very High Very High Very High
Neuropathic pain 52 97.68 Very High Very High Very High
Central nervous system 84 96.96 Very High Very High Very High
Spinal cord 36 96.28 Very High Very High Very High
Pain 54 92.44 High High
Dorsal horn 28 92.24 High High
hyperexcitability 4 91.48 High High
Dorsal horn neuron 3 90.40 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 169 99.36 Very High Very High Very High
Temporomandibular Joint Syndrome 126 98.84 Very High Very High Very High
Neuropathic Pain 105 97.68 Very High Very High Very High
Pain 83 92.44 High High
Nervous System Injury 34 83.44 Quite High
Shock 1 75.68 Quite High
Hemorrhage 2 75.56 Quite High
Cv General 4 Under Development 1 70.00 Quite High
Cancer 10 69.20 Quite High
Stroke 1 68.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No evidence for upregulation of the P2Y12 receptor subtype in the sub-acute phases following TMJ inflammation
Positive_regulation (upregulation) of P2Y12 associated with snapping jaw and inflammation
1) Confidence 0.67 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017032 Disease Relevance 0.99 Pain Relevance 0.84
Activating P2Y12R and P2Y6R leads to chemotaxis and phagocytosis, respectively, but their functional relevance to neuropathic pain remained to be determined

P2X7 in neuropathic pain

Positive_regulation (Activating) of P2Y12R associated with neuropathic pain
2) Confidence 0.53 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072920 Disease Relevance 0.83 Pain Relevance 0.99
Involvement of PTx-sensitive Gi in the mechanism leading to Ca2+ rise by ADP further supports the idea that activation of P2Y12 receptors is responsible for ADP-induced Ca2+ movements in microglia.
Positive_regulation (activation) of P2Y12 in microglia
3) Confidence 0.49 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0 Pain Relevance 0
Despite the observed upregulation of Iba1 immunoreactivity and the morphological changes observed in microglial cells (see above), no increase in P2Y12 receptor immunoreactivity in the ipsilateral side of CFA-injected rats was observed in either the trigeminal subnucleus caudalis (p = 0.957 and p = 0.968 at 24 h and 72 h respectively; n = 7 animals) (Figure 8A-B) or in the cervical dorsal horn (p = 0.734 and p = 0.923 at 24 h and 72 h respectively; n = 7 animals) (Figure 8C-D).
Neg (no) Positive_regulation (increase) of P2Y12 in microglial cells associated with dorsal horn
4) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017032 Disease Relevance 0.32 Pain Relevance 0.67
The purinergic P2Y12 receptor is a Gi-coupled metabotropic receptor specifically activated by extracellular ADP [52] that has been shown to control the chemotaxis of CNS microglial cells in response to nucleotides [56,66].
Positive_regulation (activated) of P2Y12 in microglial cells associated with central nervous system
5) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017032 Disease Relevance 1.16 Pain Relevance 0.87
P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain.
Positive_regulation (upregulation) of P2Y12 receptor in microglia associated with neuralgia and neuropathic pain
6) Confidence 0.36 Published 2008 Journal J. Neurosci. Section Title Doc Link 18337420 Disease Relevance 0.62 Pain Relevance 0.84
Levels of VASP phosphorylation/dephosphorylation reflect P2Y12 inhibition/activation [11].
Positive_regulation (activation) of P2Y12
7) Confidence 0.21 Published 2009 Journal Thromb J Section Body Doc Link PMC2693432 Disease Relevance 0.47 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox