INT150466

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.26
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2ry2) aging (P2ry2) plasma membrane (P2ry2)
embryo development (P2ry2) lysosome (P2ry2) signal transducer activity (P2ry2)
Anatomy Link Frequency
nerve 2
P2ry2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 41 98.44 Very High Very High Very High
Neuropathic pain 7 98.32 Very High Very High Very High
cytokine 1 96.28 Very High Very High Very High
Sciatic nerve 1 92.64 High High
agonist 9 89.76 High High
Inflammation 2 87.44 High High
antagonist 3 85.00 Quite High
Spinal cord 2 84.32 Quite High
Analgesic 2 82.84 Quite High
intrathecal 2 67.28 Quite High
Disease Link Frequency Relevance Heat
Pain 47 98.44 Very High Very High Very High
Neuropathic Pain 7 98.32 Very High Very High Very High
Nervous System Injury 5 97.60 Very High Very High Very High
INFLAMMATION 4 87.44 High High
Male Infertility 2 45.36 Quite Low
Death 4 44.32 Quite Low
Nociception 2 42.72 Quite Low
Diabetes Mellitus 2 41.40 Quite Low
Hypertension 4 40.80 Quite Low
Demyelinating Disease 2 40.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it remains unknown whether any type of P2Y receptor in microglia is involved in the activation of p38 MAPK and the pain behaviors after nerve injury.
Spec (whether) Regulation (involved) of Spec (whether) Positive_regulation (type) of P2Y receptor in nerve associated with pain and nervous system injury
1) Confidence 0.37 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18337420 Disease Relevance 0.68 Pain Relevance 0.68
G protein cascade components were also only sensitive following P2Y activation.
Regulation (sensitive) of Positive_regulation (activation) of P2Y
2) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735677 Disease Relevance 0.58 Pain Relevance 0.71
Time averaged normalized sensitivities for three model outputs (cytosolic calcium, concentration of gated IP3R channels, Gq-protein activation) were computed over the parameter family as a function of P2Y and P2X activation (Fig. 6A–C).
Regulation (function) of Positive_regulation (activation) of P2Y
3) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735677 Disease Relevance 0 Pain Relevance 0.03

General Comments

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