INT150473

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 5.41
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pla2g2a) extracellular space (Pla2g2a) endoplasmic reticulum (Pla2g2a)
Anatomy Link Frequency
lung 1
Pla2g2a (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn neuron 3 96.04 Very High Very High Very High
Spinal cord 34 95.24 Very High Very High Very High
Inflammation 15 92.76 High High
Pain 21 88.80 High High
Inflammatory response 3 87.20 High High
agonist 4 87.04 High High
cva 56 84.44 Quite High
Neuropathic pain 3 82.00 Quite High
Eae 3 80.96 Quite High
Angina 5 79.04 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 58 99.76 Very High Very High Very High
Deep Vein Thrombosis 4 99.66 Very High Very High Very High
Stroke 64 99.24 Very High Very High Very High
Disease 68 98.36 Very High Very High Very High
Thrombosis Related Under Development 8 98.24 Very High Very High Very High
Coronary Artery Disease 69 97.24 Very High Very High Very High
Hypersensitivity 70 94.24 High High
Pressure And Volume Under Development 4 93.56 High High
INFLAMMATION 20 92.76 High High
Cardiovascular Disease 12 91.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vivo and in vitro inhibition studies were carried out against PLA2 with respect to the modification of the pharmacophore (substituent) to analyze the specificity for PLA2.
PLA2 Spec (analyze) Binding (specificity) of
1) Confidence 0.35 Published 2009 Journal Chem. Pharm. Bull. Section Abstract Doc Link 19122311 Disease Relevance 0.26 Pain Relevance 0.08
While the results from our study associated a distinct member of the same cytosolic type of PLA2, independent confirmation of this association is required.
PLA2 Binding (associated) of
2) Confidence 0.25 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.68 Pain Relevance 0.65
On the other hand, several studies failed to confirm this association; indeed a metanalysis of 23 of such negative studies, showed the lack of association between the PlA2 allele and the risk of myocardial infarction and this negative result persisted even after subgroup analyses [11].
PlA2 Binding (association) of associated with myocardial infarction
3) Confidence 0.11 Published 2010 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2954874 Disease Relevance 0.75 Pain Relevance 0.03
Our results only apparently differ from the finding observed in a subgroup analysis of the Physicians' health study (PHS) [24] by Ridker et al.[25] which prospectively studied the risk associated with the PlA2 polymorphism for myocardial infarction, stroke or venous thromboses and reported no associations between PlA2 polymorphism and the relative risk to develop any cardiac or cerebro-vascular event.
PlA2 Neg (no) Binding (associations) of associated with stroke, deep vein thrombosis and myocardial infarction
4) Confidence 0.10 Published 2010 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2954874 Disease Relevance 0.98 Pain Relevance 0.04
Our study suggests that the PlA2 polymorphism is associated with a more aggressive atherothrombotic disease and adversely affects the prognosis in these high risk patients.
PlA2 Binding (associated) of associated with disease
5) Confidence 0.09 Published 2010 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2954874 Disease Relevance 1.02 Pain Relevance 0.04
Weiss et al. [8] observed a strong association between the PlA2 polymorphism of the GP IIIa gene and acute coronary thrombosis, and this association was strongest in patients who had had coronary events before the age of 60 years, suggesting this polymorphism as an inherited risk factor for coronary thrombosis.
PlA2 Binding (association) of associated with thrombosis related under development
6) Confidence 0.09 Published 2010 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2954874 Disease Relevance 0.62 Pain Relevance 0.04
Agreements between Cdyn, EF50 and GL were excellent, the mean ranging from 0 to -0.71 ?
EF50 Binding (Agreements) of
7) Confidence 0.06 Published 2005 Journal Respir Res Section Body Doc Link PMC1316879 Disease Relevance 0.58 Pain Relevance 0.03
In comparison with the widely used Penh method, EF50 differs substantially in several important ways: EF50 decreases with bronchoconstriction and in line with invasively measured lung resistance or conductance is linked with a decline in VT during bronchoconstriction [7,28].
EF50 Binding (decreases) of in lung
8) Confidence 0.06 Published 2005 Journal Respir Res Section Body Doc Link PMC1316879 Disease Relevance 0.07 Pain Relevance 0
Secretory type II phospholipase A2 in culprit coronary lesions is associated with myocardial infarction.
Secretory type II phospholipase Binding (associated) of associated with myocardial infarction
9) Confidence 0.02 Published 2008 Journal Eur. J. Clin. Invest. Section Title Doc Link 18339001 Disease Relevance 0.45 Pain Relevance 0.12

General Comments

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