INT150514

Context Info Confidence 0.13 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.24 Pain Relevance 0.24

mitochondrion (Decr1, Gsr) oxidoreductase activity (Decr1, Gsr) cytoplasm (Decr1, Gsr) cytosol (Gsr) nucleus (Decr1)

Anatomy Link Frequency liver 1 Decr1 (Mus musculus) Gsr (Mus musculus)

Pain Link Frequency Relevance Heat Paracetamol 3 86.32 Analgesic 1 25.00

Disease Link Frequency Relevance Heat Injury 1 84.08 Toxicity 2 76.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The high level of ME-1 expression in liver, and its involvement in NADPH production, suggests reduced ME-1 activity might compromise hepatic production of reduced glutathione (GSH) by the NADPH-dependent enzyme glutathione reductase, and hence affect xenobiotic detoxification.

NADPH Positive_regulation (dependent) of glutathione reductase in liver

1) Confidence 0.13 Published 2008 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 18346052 Disease Relevance 0.24 Pain Relevance 0.24

General Comments

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