INT150514

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Context Info
Confidence 0.13
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.24
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Decr1, Gsr) oxidoreductase activity (Decr1, Gsr) cytoplasm (Decr1, Gsr)
cytosol (Gsr) nucleus (Decr1)
Anatomy Link Frequency
liver 1
Decr1 (Mus musculus)
Gsr (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 3 86.32 High High
Analgesic 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Injury 1 84.08 Quite High
Toxicity 2 76.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The high level of ME-1 expression in liver, and its involvement in NADPH production, suggests reduced ME-1 activity might compromise hepatic production of reduced glutathione (GSH) by the NADPH-dependent enzyme glutathione reductase, and hence affect xenobiotic detoxification.
NADPH Positive_regulation (dependent) of glutathione reductase in liver
1) Confidence 0.13 Published 2008 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 18346052 Disease Relevance 0.24 Pain Relevance 0.24

General Comments

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