INT150528

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 26
Total Number 29
Disease Relevance 30.71
Pain Relevance 5.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFSF10) extracellular space (TNFSF10) extracellular region (TNFSF10)
cell-cell signaling (TNFSF10)
Anatomy Link Frequency
articular 8
fibroblasts 6
T cells 6
colon 2
cartilage 2
TNFSF10 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 276 100.00 Very High Very High Very High
spinal inflammation 24 99.84 Very High Very High Very High
Arthritis 315 99.20 Very High Very High Very High
Inflammation 348 97.36 Very High Very High Very High
Multiple sclerosis 6 73.64 Quite High
Snapping jaw 1 50.00 Quite Low
cytokine 33 49.60 Quite Low
Pain 15 41.32 Quite Low
cINOD 12 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 1511 100.00 Very High Very High Very High
Rheumatoid Arthritis 435 100.00 Very High Very High Very High
Low Back Pain 24 99.84 Very High Very High Very High
Colon Cancer 264 99.76 Very High Very High Very High
Cancer 906 99.64 Very High Very High Very High
Ovarian Cancer 8 99.04 Very High Very High Very High
Infection 45 99.00 Very High Very High Very High
Arthritis 381 98.70 Very High Very High Very High
INFLAMMATION 339 98.42 Very High Very High Very High
Multiple Myeloma 6 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It appears as if the apoptotic effect of the over-expression of TRAIL on the synovial fibroblasts from RA patients is mediated predominantly by TRAIL R1 as its expression varied from patient to patient and the extent of apoptosis following TRAIL gene transfer seemed to correlate with its expression intensity (data not shown).
Positive_regulation (transfer) of Gene_expression (transfer) of TRAIL in fibroblasts associated with rheumatoid arthritis and apoptosis
1) Confidence 0.67 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 0.76 Pain Relevance 0.13
Although these previous results suggest that gene transfer of TRAIL could be therapeutic to treat certain pathologies associated with RA, there currently is no appropriate gene transfer system that could be used clinically to deliver TRAIL intra-articularly.
Positive_regulation (transfer) of Gene_expression (transfer) of TRAIL associated with rheumatoid arthritis
2) Confidence 0.67 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 1.19 Pain Relevance 0.15
In conclusion, upregulated expression of TRAIL might be somewhat specific for evaluation of AS.
Positive_regulation (upregulated) of Gene_expression (expression) of TRAIL associated with spinal inflammation
3) Confidence 0.67 Published 2008 Journal J. Clin. Lab. Anal. Section Abstract Doc Link 18348311 Disease Relevance 1.16 Pain Relevance 0.74
CONCLUSIONS: TRAIL and DR5 are overexpressed in displaced human TMJ disc, especially in the posterior disc attachment.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of TRAIL in TMJ
4) Confidence 0.63 Published 2010 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 20123409 Disease Relevance 0.05 Pain Relevance 0
Our previous studies with adenoviral gene transfer of membrane bound TRAIL, however, showed that it too was relatively inefficient in inducing synovial apoptosis, requiring a high multiplicity of infection to confer apoptosis in culture.
Positive_regulation (transfer) of Gene_expression (transfer) of TRAIL associated with apoptosis and infection
5) Confidence 0.49 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 0.92 Pain Relevance 0.05
The extent of apoptosis observed was similar to that observed following adenoviral gene transfer of TRAIL and FasL.


Positive_regulation (transfer) of Gene_expression (transfer) of TRAIL associated with apoptosis
6) Confidence 0.49 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 0.90 Pain Relevance 0.05
The results indicated that the expression levels of TRAIL mRNA, and serum sTRAIL were significantly elevated in AS patients, compared with RA patients and healthy controls, and there was a close association between TRAIL mRNA and sTRAIL levels.
Positive_regulation (elevated) of Gene_expression (expression) of TRAIL associated with spinal inflammation and rheumatoid arthritis
7) Confidence 0.48 Published 2008 Journal J. Clin. Lab. Anal. Section Abstract Doc Link 18348311 Disease Relevance 1.52 Pain Relevance 0.83
Analysis of synovium isolated from the rabbits treated with intra-articular injection of rTRAIL, relative to saline control, showed areas of extensive acellular debris and large fibrous regions devoid of intact cells, similar to adenoviral mediated TRAIL gene transfer.
Positive_regulation (mediated) of Gene_expression (transfer) of TRAIL in articular
8) Confidence 0.45 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1526576 Disease Relevance 1.08 Pain Relevance 0.31
rTRAIL has similar apoptotic effects as adenoviral mediated TRAIL gene transfer
Positive_regulation (mediated) of Gene_expression (transfer) of TRAIL associated with apoptosis
9) Confidence 0.45 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 0.99 Pain Relevance 0.03
To test the possibility that TRAIL might be able to induce apoptosis of arthritic synovium, we previously examined the effects of adenoviral gene transfer of TRAIL.
Spec (examined) Positive_regulation (transfer) of Gene_expression (transfer) of TRAIL in synovium associated with apoptosis and arthritis
10) Confidence 0.45 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 1.30 Pain Relevance 0.13
However, in our experiments following intra-articular adenoviral mediated TRAIL gene transfer or with rTRAIL, no adverse effects were observed on cartilage metabolism.
Positive_regulation (mediated) of Gene_expression (transfer) of TRAIL in cartilage
11) Confidence 0.45 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 1.06 Pain Relevance 0.13
Analysis of synovium isolated from the rabbits treated with intra-articular injection of rTRAIL, relative to saline control, showed areas of extensive acellular debris and large fibrous regions devoid of intact cells, similar to adenoviral mediated TRAIL gene transfer.
Positive_regulation (transfer) of Gene_expression (transfer) of TRAIL in articular
12) Confidence 0.45 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1526576 Disease Relevance 1.08 Pain Relevance 0.31
In our previous experiments, we found that synovial fibroblasts in culture from different RA patients were partially sensitive to adenoviral mediated TRAIL gene transfer at high multiplicity of infection.
Positive_regulation (mediated) of Gene_expression (transfer) of TRAIL in fibroblasts associated with rheumatoid arthritis and infection
13) Confidence 0.45 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 0.87 Pain Relevance 0.16
It appears as if the apoptotic effect of the over-expression of TRAIL on the synovial fibroblasts from RA patients is mediated predominantly by TRAIL R1 as its expression varied from patient to patient and the extent of apoptosis following TRAIL gene transfer seemed to correlate with its expression intensity (data not shown).
Positive_regulation (mediated) of Gene_expression (over) of TRAIL in fibroblasts associated with rheumatoid arthritis and apoptosis
14) Confidence 0.45 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 0.85 Pain Relevance 0.16
The results of this study clearly demonstrate that intra-articular injection of the recombinant human TRAIL protein results in induction of synovial apoptosis and reduction of the leukocytic infiltrate in inflamed rabbit knees, similar to the effect of intra-articular adenoviral mediated TRAIL gene transfer.
Positive_regulation (mediated) of Gene_expression (transfer) of TRAIL in articular associated with inflammation and apoptosis
15) Confidence 0.45 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 1.04 Pain Relevance 0.27
rTRAIL has similar apoptotic effects as adenoviral mediated TRAIL gene transfer
Positive_regulation (transfer) of Gene_expression (transfer) of TRAIL associated with apoptosis
16) Confidence 0.45 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 0.99 Pain Relevance 0.03
There was no significant difference between rTRAIL treated and Ad-mTRAIL treated rabbit arthritic joints, however, suggesting that rTRAIL is as efficient as gene transfer of TRAIL for inducing synovial apoptosis.


Positive_regulation (transfer) of Gene_expression (transfer) of TRAIL in joints associated with apoptosis and arthritis
17) Confidence 0.45 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 1.44 Pain Relevance 0.07
We next investigated the expression of TRAIL and its receptors on CD8+ T cells of RA patients and compared with healthy controls, similar to CD4+ T cells, we found significant differences between the two groups as shown in Figure 3A (p < 0.05).
Positive_regulation (receptors) of Spec (investigated) Gene_expression (expression) of TRAIL in T cells associated with arthritis
18) Confidence 0.40 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 0.66 Pain Relevance 0.27
The ability of rTRAIL to induce tumor specific apoptosis as well as the ability of intra-articular TRAIL gene transfer to induce synovial apoptosis suggest that intra-articular injection of rTRAIL also might be able to induce apoptosis of hyperplastic synovium.
Positive_regulation (transfer) of Gene_expression (transfer) of TRAIL in articular associated with cancer, apoptosis and hyperplasia
19) Confidence 0.39 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 1.43 Pain Relevance 0.16
The results indicated that the expression levels of TRAIL mRNA, and serum sTRAIL were significantly elevated in AS patients, compared with RA patients and healthy controls, and there was a close association between TRAIL mRNA and sTRAIL levels.
Positive_regulation (elevated) of Gene_expression (expression) of sTRAIL associated with spinal inflammation and rheumatoid arthritis
20) Confidence 0.39 Published 2008 Journal J. Clin. Lab. Anal. Section Abstract Doc Link 18348311 Disease Relevance 1.52 Pain Relevance 0.83

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