INT150538

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRM1, TNF) Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1)
intracellular (TNF) extracellular matrix organization (TNF) signal transducer activity (OPRM1)
Anatomy Link Frequency
monocytes 2
OPRM1 (Homo sapiens)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 3 50.00 Quite Low
mu opioid receptor 1 50.00 Quite Low
cytokine 1 10.00 Low Low
Inflammation 1 10.00 Low Low
opioid receptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 2 50.00 Quite Low
Necrosis 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: The mu opioid receptor mediates morphine-induced TNF and IL-6 inhibition in PGN-stimulated monocytes, but not in PBMCs.
mu opioid receptor Positive_regulation (mediates) of Negative_regulation (inhibition) of TNF in monocytes
1) Confidence 0.08 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18349186 Disease Relevance 0 Pain Relevance 0

General Comments

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