INT15054

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Context Info
Confidence 0.77
First Reported 1980
Last Reported 2010
Negated 15
Speculated 0
Reported most in Body
Documents 48
Total Number 65
Disease Relevance 42.52
Pain Relevance 10.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mme) plasma membrane (Mme)
Anatomy Link Frequency
lung 9
plasma 3
smooth muscle 2
bone marrow 2
brain 2
Mme (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 12 100.00 Very High Very High Very High
Opioid 12 100.00 Very High Very High Very High
Analgesic 9 100.00 Very High Very High Very High
Delta opioid receptors 2 100.00 Very High Very High Very High
endometriosis 76 99.96 Very High Very High Very High
Enkephalin 36 99.40 Very High Very High Very High
Inflammation 236 99.32 Very High Very High Very High
Spinal cord 25 99.24 Very High Very High Very High
Antinociceptive 5 98.88 Very High Very High Very High
Morphine 15 98.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 20 100.00 Very High Very High Very High
Targeted Disruption 593 99.98 Very High Very High Very High
Adult Respiratory Distress Syndrome 1585 99.96 Very High Very High Very High
Endometriosis (extended) 80 99.96 Very High Very High Very High
Cancer 160 99.86 Very High Very High Very High
Follicular Lymphoma 52 99.44 Very High Very High Very High
INFLAMMATION 259 99.32 Very High Very High Very High
Lymphatic System Cancer 264 99.12 Very High Very High Very High
Mantle-cell Lymphoma 62 99.04 Very High Very High Very High
Myocardial Infarction 4 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our immuno-histochemical studies showed that NEP was expressed in the alveolar wall, most prominently in type II alveolar epithelium, and that this expression was decreased by the epithelial sloughing associated with ALI.
Gene_expression (expressed) of NEP in epithelium associated with adult respiratory distress syndrome
1) Confidence 0.77 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.86 Pain Relevance 0.06
Furthermore, the expression and activity of neprilysin, an A?
Gene_expression (expression) of neprilysin
2) Confidence 0.75 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.79 Pain Relevance 0.06
A previous study found that the expression of NEP on circulating PMN was reduced in humans challenged with LPS [40].
Gene_expression (expression) of NEP
3) Confidence 0.67 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 1.02 Pain Relevance 0.15
Previous studies have observed the expression of NEP on the surface of PMN [38,39].
Gene_expression (expression) of NEP
4) Confidence 0.67 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.95 Pain Relevance 0.16
Although the intratracheal instillation of both LPS and HCl recruited PMN into the lung, the immuno-histochemical expression of NEP in the injured lungs showed less intense staining of the PMN than of the alveolar walls (Figure 4C &4D).
Gene_expression (expression) of NEP in lungs
5) Confidence 0.67 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.30 Pain Relevance 0.04
Immuno-cytochemistry of the BALF cytospin preparations also showed that the expression of NEP in infiltrating inflammatory cells (Figure 4F) and resident alveolar macrophages (Figure 4E) was low.


Gene_expression (expression) of NEP in alveolar macrophages associated with inflammation
6) Confidence 0.67 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.27 Pain Relevance 0.05
Thus, the NEP expression was most likely down-regulated on the PMN that were recruited and activated during ALI/ARDS.
Gene_expression (expression) of NEP associated with adult respiratory distress syndrome
7) Confidence 0.67 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.99 Pain Relevance 0.14
Enkephalinase, a dipeptidyl carboxypeptidase cleaving the Gly3-Phe4 bond of enkephalins and distinct fropm angiotensin coverting enzyme (ACE), might be selectively involved in enkephalinergic transmission.
Gene_expression (cleaving) of Enkephalinase associated with enkephalin
8) Confidence 0.66 Published 1980 Journal Nature Section Abstract Doc Link 7001254 Disease Relevance 0 Pain Relevance 0.46
degrading enzymes such as neprilysin (NEP) and insulin-degrading enzyme (IDE), have been suggested as potential methods of reducing the level of existing A?
Gene_expression (enzyme) of neprilysin
9) Confidence 0.65 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536544 Disease Relevance 0.75 Pain Relevance 0
degrading enzymes such as neprilysin (NEP) and insulin-degrading enzyme (IDE), have been suggested as potential methods of reducing the level of existing A?
Gene_expression (enzymes) of neprilysin
10) Confidence 0.65 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536544 Disease Relevance 0.74 Pain Relevance 0
We conclude that deletion of the NEP gene results in an opioid-related increase in thermonociceptive threshold.
Gene_expression (deletion) of NEP gene associated with opioid
11) Confidence 0.64 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9347938 Disease Relevance 0.38 Pain Relevance 1.47
New carboxyalkyl inhibitors of brain enkephalinase: synthesis, biological activity, and analgesic properties.
Gene_expression (synthesis) of brain enkephalinase in brain associated with analgesic
12) Confidence 0.63 Published 1983 Journal J. Med. Chem. Section Title Doc Link 6298420 Disease Relevance 0 Pain Relevance 0.65
The in vitro enkephalinase inhibition data and some in vivo analgesic data are presented for these compounds.
Gene_expression (presented) of enkephalinase associated with analgesic
13) Confidence 0.60 Published 1989 Journal J. Med. Chem. Section Abstract Doc Link 2585440 Disease Relevance 0 Pain Relevance 0.23
To determine whether the decrease in lung NEP activity associated with ALI was due to a decrease in the expression of NEP protein in the lung, we measured the NEP protein content in lung homogenates using Western immunoblotting, and found that the expression of NEP protein in the lung in LPS-induced ALI was < 60% of the expression measured under control conditions (Figure 6).


Gene_expression (expression) of NEP protein in lung associated with adult respiratory distress syndrome
14) Confidence 0.60 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.62 Pain Relevance 0
Inhibition of NEP gene expression in the lung tissue of mice with acute lung injury
Gene_expression (expression) of NEP gene in lung associated with adult respiratory distress syndrome
15) Confidence 0.60 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.58 Pain Relevance 0
To determine whether the decrease in lung NEP activity associated with ALI was due to a decrease in the expression of NEP protein in the lung, we measured the NEP protein content in lung homogenates using Western immunoblotting, and found that the expression of NEP protein in the lung in LPS-induced ALI was < 60% of the expression measured under control conditions (Figure 6).


Gene_expression (expression) of NEP protein in lung associated with adult respiratory distress syndrome
16) Confidence 0.60 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.56 Pain Relevance 0
On immunohistochemical staining for estrogen and progesterone receptors, the cellular nuclei of glandular cavity walls were mainly found to be positive for both, and cells in the edematous interstitium around the glandular cavity were positive for CD10.
Gene_expression (positive) of CD10 in cavity
17) Confidence 0.59 Published 2010 Journal J. Dermatol. Section Abstract Doc Link 20536670 Disease Relevance 0.96 Pain Relevance 0.35
Elevated NEP activity in the BALF of mice with acute lung injury
Gene_expression (activity) of NEP in lung associated with adult respiratory distress syndrome
18) Confidence 0.59 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.26 Pain Relevance 0
As was observed in patients, the plasma NEP activity was lower in 5 LPS-treated (0.50 ± 0.05 pmol/min/?
Gene_expression (activity) of NEP in plasma
19) Confidence 0.59 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.29 Pain Relevance 0.04
The NEP activity measured in the control and the ALI/ARDS groups was 0.22 ± 0.03 and 0.07 ± 0.02 pmol/min/?
Gene_expression (activity) of NEP associated with adult respiratory distress syndrome
20) Confidence 0.59 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.80 Pain Relevance 0

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