INT150540

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Context Info
Confidence 0.45
First Reported 2003
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 50
Total Number 52
Disease Relevance 35.86
Pain Relevance 10.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR2) plasma membrane (TLR2) intracellular (TLR2)
cytoplasm (TLR2)
Anatomy Link Frequency
macrophages 8
NK cells 3
epithelial cells 2
dendritic cells 1
nucleus 1
TLR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 935 99.56 Very High Very High Very High
Inflammatory mediators 48 99.44 Very High Very High Very High
Inflammatory response 113 99.26 Very High Very High Very High
Inflammation 624 98.88 Very High Very High Very High
cytokine 674 98.80 Very High Very High Very High
agonist 111 98.56 Very High Very High Very High
metalloproteinase 61 96.16 Very High Very High Very High
tolerance 18 94.20 High High
analgesia 20 92.96 High High
Arthritis 59 90.68 High High
Disease Link Frequency Relevance Heat
Hemophilus Infection 322 99.98 Very High Very High Very High
Gram Positive Bacterium Infection 2 99.98 Very High Very High Very High
Infection 477 99.64 Very High Very High Very High
Insulin Resistance 12 99.64 Very High Very High Very High
Rheumatoid Arthritis 936 99.56 Very High Very High Very High
Injury 36 99.56 Very High Very High Very High
INFLAMMATION 785 99.44 Very High Very High Very High
Mycobacterial Infection 51 99.42 Very High Very High Very High
Acne 22 99.42 Very High Very High Very High
Malaria 166 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TLR2 predominantly recognizes components from Gram-positive bacteria such as lipoteichoic acid (LTA) and peptidoglycan (PGN) [6].
TLR2 Binding (recognizes) of
1) Confidence 0.45 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.35 Pain Relevance 0.07
For example in the mouse model of tuberculosis, 38 kDa glycolipid and PIM6 are sensed through TLR4 and have been found to trigger a protective type Th1 cytokine response in the lungs during Mycobacterium tuberculosis (M.tb) infection [15,16], whereas TLR2 ligation by mycobacterial liparabinomannan modulates inflammatory responses in mouse macrophages [17].
TLR2 Binding (ligation) of in macrophages associated with mycobacterial infection, inflammatory response, infection and cytokine
2) Confidence 0.44 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.66 Pain Relevance 0.20
For example, mycobacteria contain ligands for TLR2 and TLR4.
TLR2 Binding (ligands) of
3) Confidence 0.39 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 1.21 Pain Relevance 0.07
Interactions between TLR2 and mu opioid intracellular pathways remain to be studied to delineate these morphine immunosuppressive effects.


TLR2 Binding (Interactions) of
4) Confidence 0.35 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18349186 Disease Relevance 0 Pain Relevance 0
A cell wall component, peptidoglycan (PGN) of gram-positive bacteria is the preferred ligand of the TLR2 homodimer, and lipopolysaccharides (LPS) of gram-negative bacteria is recognized by TLR4 [4].
TLR2 Binding (ligand) of
5) Confidence 0.34 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.06 Pain Relevance 0.09
The TLR1/TLR2 heterodimer recognizes tri-acyl lipopeptides while TLR2/TLR6 recognizes lipotechoic acid (LTA) and di-acyl lipopeptides produced by mycoplasma [8-10].
TLR2 Binding (recognizes) of associated with bacterial respiratory disease
6) Confidence 0.32 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.17 Pain Relevance 0.07
The TLR1/TLR2 heterodimer recognizes tri-acyl lipopeptides while TLR2/TLR6 recognizes lipotechoic acid (LTA) and di-acyl lipopeptides produced by mycoplasma [8-10].
TLR2 Binding (recognizes) of associated with bacterial respiratory disease
7) Confidence 0.32 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.18 Pain Relevance 0.08
It might be that the increase in immunoreactivity for TLR2, TLR3 and TLR4 seen after allergen challenge only persists for a limited period of time.
TLR2 Spec (might) Binding (immunoreactivity) of
8) Confidence 0.31 Published 2005 Journal Respir Res Section Body Doc Link PMC1243240 Disease Relevance 0.07 Pain Relevance 0.03
Moreover, the TLR2 down-regulation was mainly seen in patients with Löfgren's syndrome, possibly indicating that these patients respond to a particular ligand that specifically binds to TLR2.
TLR2 Binding (binds) of associated with syndrome
9) Confidence 0.29 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 0.56 Pain Relevance 0.09
The other important receptors in the immune system, TLR family members (TLR2 and TLR4), which recognize pathogens by means of conserved structural features of the microbes such as LPS for Gram-negative bacteria, would involve in activating the MyD88/IRAK signaling cascade, which bifurcates and leads to NF-kB and c-Jun/ATF2/TCF activation [17].
TLR2 Neg (negative) Binding (recognize) of in immune system
10) Confidence 0.25 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2567339 Disease Relevance 0.23 Pain Relevance 0.15
NTHi first interacts with its receptors of host cells such as Toll-like receptor 2 (TLR2) [14], and leads to the activation of multiple signaling cascades resulting in the up-regulation of inflammatory cytokines such as TNF-?.
Toll-like receptor 2 Binding (interacts) of associated with hemophilus infection, inflammation and cytokine
11) Confidence 0.24 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1368979 Disease Relevance 1.12 Pain Relevance 0.25
NTHi first interacts with its receptors of host cells such as Toll-like receptor 2 (TLR2) [14], and leads to the activation of multiple signaling cascades resulting in the up-regulation of inflammatory cytokines such as TNF-?.
TLR2 Binding (interacts) of associated with hemophilus infection, inflammation and cytokine
12) Confidence 0.24 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1368979 Disease Relevance 1.13 Pain Relevance 0.25
Li and colleagues demonstrated that NTHi binds to and activates toll-like receptor 2 (TLR2) on the surface of epithelial cells [11].
TLR2 Binding (binds) of in epithelial cells associated with hemophilus infection
13) Confidence 0.23 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1368979 Disease Relevance 1.10 Pain Relevance 0.13
TLR2 (Online Mendelian Inheritancce in Man (OMIM):603028), as a heterodimer with TLR1 (OMIM: 601194) or TLR6 (OMIM: 605403), mediates recognition of several mycobacterial motifs, including lipopeptides, the 19 kDa protein, lipoarabinomannan (LAM) [1],[27],[28].
TLR2 Binding (recognition) of
14) Confidence 0.23 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2330092 Disease Relevance 0.99 Pain Relevance 0.18
TLR2 and TLR4 recognize lipoproteins and lipopolysaccharide (LPS), respectively.
TLR2 Binding (recognize) of
15) Confidence 0.23 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 1.63 Pain Relevance 0.20
To address PRR surface expression on T cells, PBMCs from patients as well as from healthy controls were incubated with mAbs against CD4, CD14, CD28, TLR4 and TLR2, and were analysed by flow cytometry.
TLR2 Spec (analysed) Binding (mAbs) of in T cells
16) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.52 Pain Relevance 0.31
The list of TLR ligands now includes malaria-derived molecules: Pf toxin, glycosylphosphatidylinisitol is recognized by TLR2 and TLR4, whereas parasite DNA complexed with haemozoin is a TLR9 ligand (91–93).
TLR2 Binding (recognized) of associated with malaria
17) Confidence 0.22 Published 2009 Journal Parasite Immunology Section Body Doc Link PMC2759986 Disease Relevance 0.87 Pain Relevance 0
Results demonstrated that all clostridia were well recognized by TLR2 alone and that responses were greatest when TLR2 was co-expressed with TLR6.
TLR2 Binding (recognized) of
18) Confidence 0.22 Published 2010 Journal Anaerobe Section Abstract Doc Link 19559804 Disease Relevance 0.63 Pain Relevance 0.24
Salmonella typhi porins are recognized by TLR2 and TLR4 [126], and they induce high antibody titers that persist during the whole lifetime of mice [127].
TLR2 Binding (recognized) of
19) Confidence 0.22 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817369 Disease Relevance 0.58 Pain Relevance 0.04
Li and colleagues demonstrated that NTHi binds to and activates toll-like receptor 2 (TLR2) on the surface of epithelial cells [11].
toll-like receptor 2 Binding (binds) of in epithelial cells associated with hemophilus infection
20) Confidence 0.20 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1368979 Disease Relevance 1.10 Pain Relevance 0.13

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