INT150546

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.14
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAP2K6) nucleoplasm (MAP2K6) signal transduction (MAP2K6)
cytoskeleton (MAP2K6) nucleus (MAP2K6) response to stress (MAP2K6)
MAP2K6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 103 98.28 Very High Very High Very High
Morphine 65 91.56 High High
opioid receptor 9 70.24 Quite High
opiate 6 59.72 Quite High
Opioid 13 50.00 Quite Low
Analgesic 5 49.64 Quite Low
Endogenous opioid 1 38.12 Quite Low
Pain 9 35.60 Quite Low
Inflammation 18 10.00 Low Low
cytokine 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 104 98.28 Very High Very High Very High
Apoptosis 6 93.96 High High
Targeted Disruption 3 78.96 Quite High
Increased Venous Pressure Under Development 1 67.04 Quite High
Pain 8 35.60 Quite Low
Cancer 17 32.20 Quite Low
Metastasis 2 5.64 Low Low
INFLAMMATION 15 5.00 Very Low Very Low Very Low
Arthritis 9 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sevoflurane exposure also induced phosphorylation of apoptosis signal-regulating kinase-1 (ASK1), MAP kinase kinases 3 and 6 (MKK3/MKK6), and ATF-2.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of MKK6
1) Confidence 0.49 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18349187 Disease Relevance 0.07 Pain Relevance 0
-induced phosphorylation of both MKK3 and MKK6 in a dose dependent manner with the maximum inhibitory effect of PE being at 50 ?
Positive_regulation (induced) of Phosphorylation (phosphorylation) of MKK6
2) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.91 Pain Relevance 0.42
The basic arrangement includes a sensor (receptor) working upstream of a core module consisting of three kinases: a MAPK kinase kinase (MAPKKK) that phosphorylates and activates a MAPK kinase (MAPKK), which in turn activates MAPK.6 But also many receptors tyrosine kinases have been shown to activate the MAPK pathway.7 Previous studies have proposed nitric oxide (NO) as being the downstream mediator of the morphine effects.
Positive_regulation (phosphorylates) of Phosphorylation (phosphorylates) of MAPKK associated with morphine
3) Confidence 0.04 Published 2009 Journal Journal of pain research Section Body Doc Link PMC3004619 Disease Relevance 0.16 Pain Relevance 0.52

General Comments

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