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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) DNA binding (Creb1)
cytoplasm (Homer1) nucleolus (Creb1) nucleus (Creb1)
Creb1 (Rattus norvegicus)
Homer1 (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 1 100.00 Very High Very High Very High
projection neuron 1 86.08 High High
Glutamate receptor 1 75.00 Quite High
Dopamine 1 71.04 Quite High


Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upon activation, mGluR1/5 signals activate extracellular signal-regulated kinases (ERKs) which in turn phosphorylate transcription factors such as cAMP response element-binding protein (CREB) and Elk-1, and thereby facilitate immediate early gene and opioid peptide gene expression.
CREB Positive_regulation (facilitate) of Gene_expression (expression) of immediate early gene associated with opioid
1) Confidence 0.00 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18351459 Disease Relevance 0 Pain Relevance 0.22

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