INT150596

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.14
Pain Relevance 2.59

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signal transduction (Oprd1, Oprk1) plasma membrane (Oprd1, Oprk1) signal transducer activity (Oprd1, Oprk1)
cytoplasm (Oprd1)
Oprd1 (Mus musculus)
Oprk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 8 100.00 Very High Very High Very High
opioid receptor 4 100.00 Very High Very High Very High
Antinociceptive 4 90.96 High High
Analgesic 6 88.60 High High
Morphine 10 85.72 High High
antinociception 4 85.04 High High
agonist 6 83.92 Quite High
analgesia 2 83.04 Quite High
addiction 4 82.52 Quite High
Physical dependence 6 70.56 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 6 70.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LPK-26 showed a high affinity to kappa-opioid receptor with the Ki value of 0.64 nM and the low affinities to micro-opioid receptor and delta-opioid receptor with the Ki values of 1170 nM and >10,000 nM, respectively.
delta-opioid receptor Binding (affinity) of kappa-opioid receptor associated with kappa opioid receptor and opioid receptor
1) Confidence 0.08 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18353307 Disease Relevance 0.07 Pain Relevance 1.29
LPK-26 showed a high affinity to kappa-opioid receptor with the Ki value of 0.64 nM and the low affinities to micro-opioid receptor and delta-opioid receptor with the Ki values of 1170 nM and >10,000 nM, respectively.
delta-opioid receptor Binding (affinity) of kappa-opioid receptor associated with kappa opioid receptor and opioid receptor
2) Confidence 0.08 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18353307 Disease Relevance 0.07 Pain Relevance 1.29

General Comments

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