INT150640

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.31
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (KNG1) extracellular region (KNG1) plasma membrane (KNG1)
Anatomy Link Frequency
plasma 2
KNG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 18 100.00 Very High Very High Very High
bradykinin 13 100.00 Very High Very High Very High
Inflammation 11 99.76 Very High Very High Very High
Pain 3 99.04 Very High Very High Very High
b2 receptor 16 95.56 Very High Very High Very High
antagonist 2 86.72 High High
Analgesic 2 74.32 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 4 100.00 Very High Very High Very High
INFLAMMATION 10 99.76 Very High Very High Very High
Pain 3 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of aspirin on bradykinin binding to cell-surface receptor and on signal transduction were studied in CHO-K1 cells, stably expressing the human B2 receptor.
Regulation (effect) of bradykinin Binding (binding) of associated with aspirin, b2 receptor and bradykinin
1) Confidence 0.35 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18355801 Disease Relevance 0.37 Pain Relevance 0.75
Plasminogen activation controls the formation of complement anaphylotoxins (responsible for vasodilatation, increase of venular permeability and leukocyte chemotaxis) and of bradykinin (which accounts for vasodilatation, increase of venular permeability and pain) by regulating the plasma contact system.
Regulation (controls) of bradykinin Binding (formation) of in plasma associated with pain, increased venous pressure under development and bradykinin
2) Confidence 0.25 Published 2008 Journal Front. Biosci. Section Abstract Doc Link 18508538 Disease Relevance 0.70 Pain Relevance 0.35
Aspirin does not influence the receptor ability to transduce bradykinin binding into activation of G-proteins and phospholipase C.
Neg (not) Regulation (influence) of bradykinin Binding (binding) of associated with aspirin and bradykinin
3) Confidence 0.21 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18355801 Disease Relevance 0.24 Pain Relevance 1.09

General Comments

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