INT150675

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.11
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Eif2ak3) translation (Eif2ak3) kinase activity (Eif2ak3)
cell (Eif2ak3) response to stress (Eif2ak3) cytoplasm (Eif2ak3)
Anatomy Link Frequency
nerve 2
brains 2
dorsal horn 2
Eif2ak3 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 6 100.00 Very High Very High Very High
spinal dorsal horn 20 99.76 Very High Very High Very High
Pain 23 99.66 Very High Very High Very High
c fibre 17 99.32 Very High Very High Very High
dorsal root ganglion 18 98.04 Very High Very High Very High
substance P 7 95.36 Very High Very High Very High
Dorsal horn neuron 5 94.80 High High
Dorsal horn 16 94.56 High High
Glutamate 2 92.96 High High
nMDA receptor 12 92.16 High High
Disease Link Frequency Relevance Heat
Nociception 32 99.80 Very High Very High Very High
Ganglion Cysts 25 98.04 Very High Very High Very High
Injury 9 84.96 Quite High
Nervous System Injury 39 80.24 Quite High
Increased Venous Pressure Under Development 1 44.24 Quite Low
Neurological Disease 1 36.84 Quite Low
Pain 18 36.32 Quite Low
Neuropathic Pain 53 24.28 Low Low
Hyperalgesia 8 23.28 Low Low
Demyelinating Disease 8 9.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The differential effect of morphine and beta-endorphin administered intracerebroventricularly on pERK and pCaMK-II expression induced by various nociceptive stimuli in mice brains.
Regulation (effect) of Gene_expression (expression) of pERK in brains associated with nociception, pain and morphine
1) Confidence 0.40 Published 2008 Journal Neuropeptides Section Title Doc Link 18359081 Disease Relevance 0.10 Pain Relevance 0.65
The lack of pERK signals induced by 2000 Hz stimuli was consistent with the report by Ji et al. [3], who demonstrated that no pERK signals were observed in the dorsal horn following A?
Regulation (lack) of Gene_expression (signals) of pERK in dorsal horn associated with dorsal horn
2) Confidence 0.31 Published 2008 Journal Mol Pain Section Body Doc Link PMC2488330 Disease Relevance 0.61 Pain Relevance 0.78
Interestingly, we previously found that the pERK expression was specific for nociceptive C-fiber- and A?
Regulation (specific) of Gene_expression (expression) of pERK associated with nociception and c fibre
3) Confidence 0.28 Published 2008 Journal Mol Pain Section Body Doc Link PMC2599895 Disease Relevance 0.31 Pain Relevance 0.32
In sham-operated wild-type mice, no significant pERK signals were observed by the control treatment without electrical stimulation or by transcutaneous nerve stimuli for A?
Regulation (observed) of Gene_expression (signals) of pERK in nerve
4) Confidence 0.24 Published 2008 Journal Mol Pain Section Body Doc Link PMC2599895 Disease Relevance 0.08 Pain Relevance 0.18

General Comments

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