INT150676

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Context Info
Confidence 0.45
First Reported 2002
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 30
Total Number 34
Disease Relevance 10.06
Pain Relevance 12.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) protein complex (Mapk1)
cytoplasm (Mapk1) cytosol (Mapk1) signal transduction (Mapk1)
Anatomy Link Frequency
frontal cortex 14
spinal cord 4
brainstem 4
hypothalamus 4
retinas 2
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 13 99.98 Very High Very High Very High
Inflammatory stimuli 11 99.98 Very High Very High Very High
Morphine 102 99.76 Very High Very High Very High
Spinal cord 176 99.68 Very High Very High Very High
medulla 76 99.48 Very High Very High Very High
Hippocampus 22 98.56 Very High Very High Very High
Intracerebroventricular 2 98.44 Very High Very High Very High
Nucleus accumbens 30 97.92 Very High Very High Very High
Opioid 92 97.88 Very High Very High Very High
opioid receptor 48 97.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 30 100.00 Very High Very High Very High
Congenital Anomalies 12 99.84 Very High Very High Very High
INFLAMMATION 414 99.82 Very High Very High Very High
Targeted Disruption 87 97.16 Very High Very High Very High
Apoptosis 23 96.48 Very High Very High Very High
Cancer 366 92.24 High High
Obesity 106 91.60 High High
Glioma 56 91.56 High High
Motor Neuron Diseases 168 89.68 High High
Carcinoma 2 87.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DSLET-mediated ERK activation was significantly inhibited by the Src kinase inhibitor, PP1 (10 ?
Positive_regulation (mediated) of Gene_expression (activation) of ERK
1) Confidence 0.45 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0 Pain Relevance 0.16
While the EGFR does not appear to be phosphorylated during DSLET-mediated ERK activation, it is possible that the EGFR is somehow involved in this response when it is present.
Positive_regulation (mediated) of Gene_expression (activation) of ERK
2) Confidence 0.45 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0.23 Pain Relevance 0.24
In this report, we questioned whether the EGFR acts as a surrogate scaffold during ERK activation through the ?
Spec (whether) Positive_regulation (during) of Gene_expression (activation) of ERK
3) Confidence 0.45 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0 Pain Relevance 0.07
PTX did not attenuate EGF-mediated ERK activation (Figure 2a), although this response was completely blocked by the EGFR kinase inhibitor, AG1478 (1 ?
Positive_regulation (mediated) of Gene_expression (activation) of ERK
4) Confidence 0.45 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0 Pain Relevance 0.23
Morphine reexposure induces the decrease of receptor for activated C-kinase 1 protein (RACK1) levels in frontal cortex, and the increase of p-ERK (extracellular signal-regulated kinase) levels in mouse frontal cortex, striatum, hippocampus and nucleus accumbens (NAcc).
Positive_regulation (induces) of Gene_expression (levels) of extracellular signal-regulated kinase in frontal cortex associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
5) Confidence 0.44 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.20 Pain Relevance 0.52
Morphine reexposure induces the decrease of receptor for activated C-kinase 1 protein (RACK1) levels in frontal cortex, and the increase of p-ERK (extracellular signal-regulated kinase) levels in mouse frontal cortex, striatum, hippocampus and nucleus accumbens (NAcc).
Positive_regulation (activated) of Gene_expression (levels) of extracellular signal-regulated kinase in frontal cortex associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
6) Confidence 0.44 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.20 Pain Relevance 0.52
Morphine reexposure induces the decrease of receptor for activated C-kinase 1 protein (RACK1) levels in frontal cortex, and the increase of p-ERK (extracellular signal-regulated kinase) levels in mouse frontal cortex, striatum, hippocampus and nucleus accumbens (NAcc).
Positive_regulation (activated) of Gene_expression (levels) of ERK in frontal cortex associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
7) Confidence 0.44 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.20 Pain Relevance 0.52
Morphine reexposure induces the decrease of receptor for activated C-kinase 1 protein (RACK1) levels in frontal cortex, and the increase of p-ERK (extracellular signal-regulated kinase) levels in mouse frontal cortex, striatum, hippocampus and nucleus accumbens (NAcc).
Positive_regulation (induces) of Gene_expression (levels) of ERK in frontal cortex associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
8) Confidence 0.44 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.20 Pain Relevance 0.52
Lignocaine and TTX significantly attenuated the effects of LPS on TLR-4, NF-kappaB, ERK and p38 MAPK expression, but not on JNK.
Neg (not) Positive_regulation (on) of Gene_expression (expression) of ERK
9) Confidence 0.33 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18505446 Disease Relevance 0.11 Pain Relevance 0.36
In the immunoblot assay, the increases of phosphorylated extracellular signal-regulated protein kinase (pERK) as well as phosphorylated calcium/calmodulin-dependent protein kinase IIalpha (pCaMK-IIalpha) expression induced by noxious stimuli were attenuated by intracerebroventricular (i.c.v.) beta-endorphin pretreatment in the hypothalamus, but not by i.c.v. morphine pretreatment.
Positive_regulation (increases) of Gene_expression (expression) of extracellular signal-regulated protein kinase in hypothalamus associated with intracerebroventricular and morphine
10) Confidence 0.27 Published 2008 Journal Neuropeptides Section Abstract Doc Link 18359081 Disease Relevance 0.07 Pain Relevance 0.49
In the immunoblot assay, the increases of phosphorylated extracellular signal-regulated protein kinase (pERK) as well as phosphorylated calcium/calmodulin-dependent protein kinase IIalpha (pCaMK-IIalpha) expression induced by noxious stimuli were attenuated by intracerebroventricular (i.c.v.) beta-endorphin pretreatment in the hypothalamus, but not by i.c.v. morphine pretreatment.
Positive_regulation (induced) of Gene_expression (expression) of extracellular signal-regulated protein kinase in hypothalamus associated with intracerebroventricular and morphine
11) Confidence 0.27 Published 2008 Journal Neuropeptides Section Abstract Doc Link 18359081 Disease Relevance 0.07 Pain Relevance 0.49
This study presents the first description of the time course of HFS-induced phosphorylation of CaMKII, ERK and CREB and altered expression of c-Fos in the SC of mice and rats.
Positive_regulation (induced) of Gene_expression (expression) of ERK associated with spinal cord
12) Confidence 0.27 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0.06 Pain Relevance 0.76
The results showed that HFS-induced increases of p-CaMKII (10 min), p-ERK (10 min) and p-CREB (2 h) protein levels were partly, but significantly reduced by pretreatment of EphB2-Fc (2 ?
Positive_regulation (increases) of Gene_expression (levels) of ERK
13) Confidence 0.27 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0 Pain Relevance 0.27
In contrast, retinas examined 8 days following LeTx treatment showed increased active ERK staining not only in the superficial layer (Fig. 7A) but also in the neovascular growths located throughout the inner and outer retinal regions (Fig. 7B, inset).
Positive_regulation (increased) of Gene_expression (staining) of ERK in retinas
14) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737623 Disease Relevance 0.16 Pain Relevance 0
Similarly, Tpl2 is dispensable for ERK activation induced by phorbol myristate acetate (PMA) (29).
Positive_regulation (induced) of Gene_expression (activation) of ERK
15) Confidence 0.21 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.72 Pain Relevance 0.32
Furthermore, BV-treatment dramatically increased the expression of phospho-ERK in the spinal cord and brainstem of familial mutant SOD1 mice (Figure 7F).
Positive_regulation (increased) of Gene_expression (expression) of ERK in brainstem associated with medulla and spinal cord
16) Confidence 0.18 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2974667 Disease Relevance 0.87 Pain Relevance 0.35
In contrast, the levels of phospho-AKT and phospho-ERK were increased in both the brainstem and spinal cord of BV-treated hSOD1 mice compared to those of control mice (Figure 7E-F).
Positive_regulation (increased) of Gene_expression (levels) of ERK in spinal cord associated with medulla and spinal cord
17) Confidence 0.18 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2974667 Disease Relevance 0.76 Pain Relevance 0.43
Specific inhibition of EGFR and TRPV1 indicated that capsaicin-induced ERK activation in A431 cells was dependent on EGFR, but not TRPV1.
Positive_regulation (induced) of Gene_expression (activation) of ERK in A431 associated with qutenza
18) Confidence 0.17 Published 2010 Journal Cancer Res. Section Abstract Doc Link 20660715 Disease Relevance 0.70 Pain Relevance 0.77
Morphine reexposure induces the decrease of receptor for activated C-kinase 1 protein (RACK1) levels in frontal cortex, and the increase of p-ERK (extracellular signal-regulated kinase) levels in mouse frontal cortex, striatum, hippocampus and nucleus accumbens (NAcc).
Positive_regulation (activated) of in nucleus accumbens Gene_expression (levels) of extracellular signal-regulated kinase in frontal cortex associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
19) Confidence 0.15 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.20 Pain Relevance 0.52
Morphine reexposure induces the decrease of receptor for activated C-kinase 1 protein (RACK1) levels in frontal cortex, and the increase of p-ERK (extracellular signal-regulated kinase) levels in mouse frontal cortex, striatum, hippocampus and nucleus accumbens (NAcc).
Positive_regulation (activated) of in hippocampus Gene_expression (levels) of ERK in frontal cortex associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
20) Confidence 0.15 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.20 Pain Relevance 0.52

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