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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.07
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Pomc, Camk2a) signal transduction (Pomc) generation of precursor metabolites and energy (Pomc)
extracellular space (Pomc) extracellular region (Pomc) plasma membrane (Camk2a)
Anatomy Link Frequency
locus coeruleus 1
Pomc (Mus musculus)
Camk2a (Mus musculus)
Pain Link Frequency Relevance Heat
Locus ceruleus 5 99.84 Very High Very High Very High
Morphine 6 98.08 Very High Very High Very High
Antinociceptive 1 88.64 High High
Intracerebroventricular 1 75.24 Quite High
Pain 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Nociception 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
I.c.v. injection of morphine significantly increased pERK as well as pCaMK-IIalpha expression in the locus coeruleus, while beta-endorphin increased only pCaMK-IIalpha in the LC.
beta-endorphin Positive_regulation (increased) of pCaMK-IIalpha in locus coeruleus associated with locus ceruleus and morphine
1) Confidence 0.47 Published 2008 Journal Neuropeptides Section Abstract Doc Link 18359081 Disease Relevance 0.07 Pain Relevance 0.80

General Comments

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