INT150729

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.26
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tlr3) signal transduction (Tlr3) endoplasmic reticulum (Tlr3)
RNA binding (Tlr3) intracellular (Tlr3) cytoplasm (Tlr3)
Anatomy Link Frequency
poly 1
nerve 1
Tlr3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 57 97.60 Very High Very High Very High
ischemia 26 97.24 Very High Very High Very High
cytokine 60 97.08 Very High Very High Very High
Brush evoked pain 5 88.12 High High
intrathecal 2 86.32 High High
agonist 14 83.60 Quite High
Peripheral nerve injury 1 83.44 Quite High
glial activation 2 81.36 Quite High
Spinal cord 1 80.68 Quite High
Neuropathic pain 1 42.16 Quite Low
Disease Link Frequency Relevance Heat
Nervous System Injury 8 99.56 Very High Very High Very High
Aging 5 99.52 Very High Very High Very High
Sepsis 6 98.64 Very High Very High Very High
INFLAMMATION 70 97.60 Very High Very High Very High
Cv Unclassified Under Development 26 97.24 Very High Very High Very High
Cancer 6 94.80 High High
Necrosis 2 94.56 High High
Cytomegalovirus Infection 2 94.48 High High
Injury 163 94.08 High High
Severe Combined Immunodeficiency 1 91.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, down-regulation of TLR3 inhibited nerve injury-induced up-regulation of spinal pro-inflammatory cytokines, such as interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha.
Negative_regulation (down-regulation) of TLR3 in nerve associated with necrosis, nervous system injury, inflammation, cancer and cytokine
1) Confidence 0.43 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18363823 Disease Relevance 1.29 Pain Relevance 0.75
These results suggest that, although TLR3 and TLR9 receptors are reduced during the aging process, poly (ICLC) and CpG ODN still have potential to be effective.

6.

Negative_regulation (reduced) of TLR3 in poly associated with aging
2) Confidence 0.22 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.59 Pain Relevance 0.03
A recent study has investigated the effect of chloroquine, an inhibitor of TLR-3, 7, 8, and 9, in a polymicrobial sepsis mouse model [91].
Negative_regulation (inhibitor) of TLR-3 associated with sepsis
3) Confidence 0.07 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 1.38 Pain Relevance 0.37

General Comments

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