INT150730

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 9
Disease Relevance 6.51
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tlr3) signal transduction (Tlr3) endoplasmic reticulum (Tlr3)
RNA binding (Tlr3) intracellular (Tlr3) cytoplasm (Tlr3)
Anatomy Link Frequency
liver 1
pancreas 1
nerve 1
brain 1
epithelial cells 1
Tlr3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 65 97.60 Very High Very High Very High
cytokine 225 97.08 Very High Very High Very High
Brush evoked pain 5 87.92 High High
intrathecal 2 86.32 High High
agonist 97 83.60 Quite High
Peripheral nerve injury 1 83.24 Quite High
glial activation 2 81.16 Quite High
Spinal cord 1 80.48 Quite High
adenocard 8 46.48 Quite Low
Neuropathic pain 1 42.16 Quite Low
Disease Link Frequency Relevance Heat
Influenza Virus Infection 736 99.84 Very High Very High Very High
Nervous System Injury 8 99.56 Very High Very High Very High
INFLAMMATION 73 97.60 Very High Very High Very High
Cancer 25 94.80 High High
Necrosis 1 94.56 High High
Neuropathic Pain 6 87.92 High High
Viral Infection 56 84.20 Quite High
Vesicular Stomatitis 8 40.64 Quite Low
Infection 280 14.64 Low Low
Toxicity 88 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, down-regulation of TLR3 inhibited nerve injury-induced up-regulation of spinal pro-inflammatory cytokines, such as interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha.
Regulation (regulation) of TLR3 in nerve associated with necrosis, nervous system injury, inflammation, cancer and cytokine
1) Confidence 0.45 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18363823 Disease Relevance 1.29 Pain Relevance 0.75
In humans, TLR3 mRNA is constitutively expressed in alveolar and bronchial epithelial cells, placenta, pancreas, liver, spleen, heart, brain and intestine, and is up-regulated by influenza virus [17, 22].
Regulation (regulated) of TLR3 in epithelial cells associated with influenza virus infection
2) Confidence 0.23 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.65 Pain Relevance 0.08
In humans, TLR3 mRNA is constitutively expressed in alveolar and bronchial epithelial cells, placenta, pancreas, liver, spleen, heart, brain and intestine, and is up-regulated by influenza virus [17, 22].
Regulation (regulated) of TLR3 in brain associated with influenza virus infection
3) Confidence 0.08 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.65 Pain Relevance 0.08
In humans, TLR3 mRNA is constitutively expressed in alveolar and bronchial epithelial cells, placenta, pancreas, liver, spleen, heart, brain and intestine, and is up-regulated by influenza virus [17, 22].
Regulation (regulated) of TLR3 in pancreas associated with influenza virus infection
4) Confidence 0.08 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.65 Pain Relevance 0.08
In humans, TLR3 mRNA is constitutively expressed in alveolar and bronchial epithelial cells, placenta, pancreas, liver, spleen, heart, brain and intestine, and is up-regulated by influenza virus [17, 22].
Regulation (regulated) of TLR3 in spleen associated with influenza virus infection
5) Confidence 0.08 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.65 Pain Relevance 0.08
In humans, TLR3 mRNA is constitutively expressed in alveolar and bronchial epithelial cells, placenta, pancreas, liver, spleen, heart, brain and intestine, and is up-regulated by influenza virus [17, 22].
Regulation (regulated) of TLR3 in intestine associated with influenza virus infection
6) Confidence 0.08 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.65 Pain Relevance 0.08
In humans, TLR3 mRNA is constitutively expressed in alveolar and bronchial epithelial cells, placenta, pancreas, liver, spleen, heart, brain and intestine, and is up-regulated by influenza virus [17, 22].
Regulation (regulated) of TLR3 in placenta associated with influenza virus infection
7) Confidence 0.08 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.65 Pain Relevance 0.08
In humans, TLR3 mRNA is constitutively expressed in alveolar and bronchial epithelial cells, placenta, pancreas, liver, spleen, heart, brain and intestine, and is up-regulated by influenza virus [17, 22].
Regulation (regulated) of TLR3 in heart associated with influenza virus infection
8) Confidence 0.08 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.65 Pain Relevance 0.08
In humans, TLR3 mRNA is constitutively expressed in alveolar and bronchial epithelial cells, placenta, pancreas, liver, spleen, heart, brain and intestine, and is up-regulated by influenza virus [17, 22].
Regulation (regulated) of TLR3 in liver associated with influenza virus infection
9) Confidence 0.08 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.65 Pain Relevance 0.08

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