INT150733

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.34
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tlr3) aging (Il1b) endoplasmic reticulum (Tlr3)
intracellular (Tlr3) cytoplasm (Tlr3) signal transduction (Tlr3)
Anatomy Link Frequency
nerve 3
Tlr3 (Mus musculus)
Il1b (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1 100.00 Very High Very High Very High
Inflammation 1 100.00 Very High Very High Very High
intrathecal 2 95.04 Very High Very High Very High
agonist 1 92.32 High High
Brush evoked pain 5 88.12 High High
Peripheral nerve injury 1 83.44 Quite High
glial activation 2 81.36 Quite High
Spinal cord 1 80.68 Quite High
Neuropathic pain 1 50.88 Quite High
Hyperesthesia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Nervous System Injury 8 100.00 Very High Very High Very High
INFLAMMATION 1 100.00 Very High Very High Very High
Cancer 1 99.16 Very High Very High Very High
Necrosis 1 98.92 Very High Very High Very High
Neuropathic Pain 6 88.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, down-regulation of TLR3 inhibited nerve injury-induced up-regulation of spinal pro-inflammatory cytokines, such as interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha.
Negative_regulation (down-regulation) of TLR3 in nerve Negative_regulation (inhibited) of Positive_regulation (up-regulation) of interleukin-1beta in nerve associated with necrosis, nervous system injury, inflammation, cancer and cytokine
1) Confidence 0.48 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18363823 Disease Relevance 1.34 Pain Relevance 0.83

General Comments

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